Reaction product of Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs. and Benzenesulfonic acid, 4-methyl- and sodium hydroxide

Short-term toxicity to fish

Description of key information

The fish 96-hr LC50 for the reaction product is 5.5 mg/L according to a 1998 EU Guideline Method C.1 study conducted under GLP 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

5.5 mg/L

Additional information

There is a second key study - a published 96 hr exposure to fish of one of the read across substances (CAS No 68411 -30 -0 sodium 4-undecylbenzenesulphonate) that comprise the reaction product. The reported 96-hr LC50 is 1.67 mg/L.

There are no fish toxicity studies for the other read across substance that comprises the reaction product (CAS No 12068 -03 -0 sodium toluene sulphonate); however, there are however two studies on closely related hydrotrope substances. The key study is a 1993 USEPA Guideline study - EPA-OTS 5797.1400 - Fish Acute Toxicity Test with sodium xylene sulphonate - CAS No 1300-72-7. The study is well documented but was not conducted under GLP compliance. Rainbow trout were exposed to the test substance for 96 hours in freshwater under static conditions. Chemical analysis was not performed. The nominal 96-hour LC50 was greater than the highest test concentration, 1000 mg/L. No deaths or abnormal behavior were observed in the test at any of the 5 concentrations. The second study is of calcium xylene sulphonate (CAS No 28088-63-3) and was also conducted per USEPA Guideline study - EPA-OTS 5797.1400. This 1994 supporting study was conducted under GLP compliance. The measured 96-hour LC50 for rainbow trout in this flow-through study was 1580 mg/L. The NOEC was 824 mg/L based on behavioral abnormalities (e.g., loss of equilibrium) at the 1580 mg/L exposure level.