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Diss Factsheets
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EC number: 910-356-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “read-across: supporting information”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.04 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- copper
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: dissolved metal fraction corresponding to nominal 4444 mg/L submission substance, dissolved Cu measured after 2 days
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 4 444 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: value recalculated based on the ratio of MnO2 and CuO in the reaction mass
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h-LC50 (Cyprinus carpio) was > 4444 mg/L (nominal); corresponding to 0.04 mg/L dissolved copper, measured after 2 days; 96h-LC20 ca. 4444 mg/L.
- Executive summary:
The study investigated the distribution of CuO nanoparticles in juvenile carp (Cyprinus carpio) and the potential toxicity (acute and sub-acute). Next to CuO nanoparticles, all tests were performed with CuO bulk material. The determination of the lethal concentration (LC50) measured during 96 hours followed the principles of OECD TG 203. The study results of the source compound were considered applicable to the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the attached document (see section 13 or find a link in cross reference).
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 143 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: value recalculated based on the ratio of MnO2 and CuO in the reaction mass
- Validity criteria fulfilled:
- yes
- Conclusions:
- The derived 96h-LC50 (rainbow trout) > 143 mg/L (limit test, 100% (v/v) saturated solution prepared at 100 mg/L test item); no toxic effects were observed.
- Executive summary:
The study used as source investigated the acute toxicity to fish acc. to OECD 203. The study results of the source compound were considered applicable to the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross reference “assessment report”.
Referenceopen allclose all
Description of key information
96h-LC50 (Rainbow trout) > 143 mg/L (limit test, 100% (v/v) saturated solution prepared at 100 mg/L, nominal, OECD 203)
Key value for chemical safety assessment
Additional information
Two reliable key studies were available for the hazard assessment of acute toxicity to fish for the submission substance reaction mass of copper oxide and manganese dioxide.
Acute toxicity of the constituent manganese dioxide to fish was investigated in a study, which was conducted under GLP conditions and in accordance with OECD 203 and EU Method C.1 (RL1, 2010). As the test material was considered to be of very low water solubility, a limit test was performed with a saturated solution prepared at 100 mg/L test material (100 % (v/v) saturated solution prepared at 100 mg/L). Two fish were observed dead in one replicate after 72 hours exposure. Given that no other mortalities were observed, and no sub-lethal effects were observed throughout the duration of the test, these mortalities were related to natural causes rather than a toxic effect of the test material. There were no sub-lethal effects of exposure observed in 14 fish exposed to a test concentration of 100% (v/v) saturated solution for a period of 96 hours. The 96-hour LC50 value was therefore considered to be > 143 mg/L (value recalculated based on the ratio of MnO2 and CuO in the reaction mass). Therefore, no toxic effects were observed up to the limit of water solubility of the test item.
The second key study investigated the acute toxicity of constituent copper oxide to fish during 96 hours and followed the principles of OECD 203 (RL 2, 2011). Eight nominal test concentrations were tested. Each concentration was run in triplicates. The dissolved copper fraction of each test concentration was determined in a parallel experiment. Fish mortality was observed in concentrations >= 1333 mg/L (value recalculated based on the ratio of MnO2 and CuO in the reaction mass). Mortality occurred in a dose-related manner, i.e. increasing number of dead fish with increasing concentrations. At the highest test concentration of 4444 mg/L (value recalculated based on the ratio of MnO2 and CuO in the reaction mass), mortality was not greater than 20%. The derived 96h-LC50 was > 4444 mg/L (nominal, corresponding to 0.04 mg/L dissolved copper measured after two days). With regard to observed sub-lethal effects, measured tail beat frequency of carp was lower for exposed fish compared to the control (no clear dose-response pattern).
Despite of shortcoming in reporting, results of the study were considered reliable. The applied test concentrations covered a wide range of concentrations (including the limit concentration of 100 mg/L acc. to OECD 203). The derived lethal effect concentrations were considered adequate to evaluate adverse effects of the submission substance in fish.
As the constituents did not cause mortality of > 50% in fish up to a nominal concentration of 100 mg/L (saturated solution), the reaction mass of copper oxide and manganese dioxide were considered non-hazardous for fish during short-term exposure.
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