Registration Dossier
Registration Dossier
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EC number: 430-750-8 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- December 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- March 1989
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- August 1996
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- no
- Type of method:
- other: calculation (Leo-Hansch method)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: theoretical calculation
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6
- Temp.:
- 20 °C
- Remarks on result:
- other: calculation
- Conclusions:
- The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method.
- Executive summary:
The partition coefficient of Urea 4 was estimated according to EU method A.8 (Leo-Hansch method), OECD Guideline 117, and EPA OPPTS 830.7570 guideline. The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method. Urea 4 was not soluble in n-octanol and only slightly soluble in water. Therefore, due to the low solubility of Urea 4 in water and n-octanol and the low sensitivity of the analytical methods available the experimental determination of the partition coefficient by any analytical technique was technically not feasible.
Reference
As Urea 4 consists of several constituents, for each constituent a partition coefficient was calculated. The partition coefficients (log Pow values) of all possible constituents are > 6.
Description of key information
The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6
- at the temperature of:
- 20 °C
Additional information
The partition coefficient of Urea 4 was estimated according to EU method A.8 (Leo-Hansch method), OECD Guideline 117, and EPA OPPTS 830.7570 guideline. The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method. Urea 4 was not soluble in n-octanol and only slightly soluble in water. Therefore, due to the low solubility of Urea 4 in water and n-octanol and the low sensitivity of the analytical methods available the experimental determination of the partition coefficient by any analytical technique was technically not feasible.
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