Registration Dossier
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EC number: 421-090-1 | CAS number: 131298-44-7 Isodecyl benzoate
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Acute Oral Toxicity Study of Isodecyl Benzoate in Rats; GLP conducted study following EPA Guideline 81-1 (1982).
A 14 day acute oral gavage rat toxicity study was conducted using five male rats and five female rats. The estimated oral LD50 for both males and females is >5.0 g/kg of body weight.
Acute Dermal Toxicity Study of Isodecyl Benzoate in Rats; GLP run study following Guideline EPA OPP 81-2 (1987).
The estimated dermal LD50 for Isodecyl Benzoate in male and female rabbits is > 2.0 g/kg of body weight.
An Acute (4-hour) inhalation Toxicity Study in the Rat via Nose-Only Exposure Toxicity Study with Isodecyl Benzoate in the Rat: Acute Toxic Class (ATC) Method; GLP conducted study conducted according to OECD Guideline 436 (2007). Average gravimetric exposure concentration of 5.5 mg/L (milligrams of test substance/Liter of air) with a range of 5.2 – 5.7 mg/L. A total of 124.1 grams of test substance was used during the exposure, resulting in a nominal concentration of 23 mg/L. Highly respirable particle size distribution measurements were an average mass median aerodynamic diameter of 2.41 µm with an average geometric standard deviation of 2.12 and 12% of particles ≤ 1.0 µm, 75% of particles ≤ 4.0 µm and 97% of particles ≤ 10 µm.
The acute inhalation LC50 in rats is > 5.5 mg/L.
Justification for classification or non-classification
The estimated oral LD50 for both males and females is >5.0 g/kg of body weight.
The estimated dermal LD50 for Isodecyl Benzoate in male and female rabbits is > 2.0 g/kg of body weight.
Isodecyl benzoate was practically non-toxic by inhalation to rats by nose-only inhalation exposure with a 4 -hour LC 50 greated than 5.5 mg/L (mean gravimetric exposure concentration) for males and females and therefore does not require classification.
No classification for acute toxicity is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
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