Registration Dossier
Registration Dossier
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EC number: 242-538-0 | CAS number: 18727-04-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
IC50 (9h) = 211 mg cobalt hydrogencitrate/L (Tetrahymena pyriformis) for growth inhibition (read-across from cobalt chloride)
Key value for chemical safety assessment
Additional information
Data on single-species toxicity tests resulting in high quality L(I)C50 values (expressed as Co) for microorganisms are summarised in Table 2 of the WHO CICAD document, 2006 (see attached document).
Data on growth inhibition of the protozoan species Tetrahymena pyiformis in 9 hour flask tests were used for the assessment (standard test organism). The IC50(9h) was at 50 mg cobalt/L, resulting in a calculated value of 211 mg cobalt hydrogencitrate/L.
A second study on the ciliate Spirostomum ambiguum showed LC50(24h) values of 11.8 mg cobalt/L using cobalt nitrate as salt, resulting in a value of 49.9 mg cobalt hydrogencitrate/L.
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