Dimethoxymethane

Boiling point

Description of key information

The pieces of information that build the weight of evidence are the following:

A) Handbook from Flick, 1991       

Purity of min. 97%       

Method not described       

BP value: 42.3°C at 760 mm HG

B) Handbook from Riddick et al., 1986 (with references to old studies from Nicolini, 1952, 1949; Timmermans, 1910, 1911, 1928 that just mention the BP value)Purity not specified       

Method not described       

BP value: 42.3°C at 1 atm

C) Publication from Reddy et al. (2004)       

Purity of 99.5% (Merck Company)       

Description of method and apparatus (Swietoslawski ebulliometer)

BP value:42.1°C at 1 atm with accuracy of ± 0.1°C

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

42.3 °C

Additional information

The weight of evidence approach is justified as determined from more than one piece of information (independent sources). We claim the reliability, relevance, adequacy and quality of the weight of evidence:

-     Reliability: Klimisch score of 2 is assigned to the studies 

-     Relevance:

o  Relevance of test material: substance purity ranges from 97% to 99.5% without affecting the reproducibility of the endpoint value. The test material is equivalent to the submission substance identity.

o  Relevance of test method and conditions: the tested method is described in Reddy et al. (2004).

o  Relevance of the endpoint: the values obtained extend over more than 90 years and show a good reproducibility.

-     Adequacy: the endpoints, whereas obtained from not internationally approved test guideline, with different sources and purity of test item lead to a clear trend: boiling point of dimethoxymethane is 42.3°C at atmospheric pressure is higher than the CLP cut-off value of 35°C leading to classification as flammable liquid category 2. 

-     Quantity: three pieces of information are considered (with 1 piece that refers to old studies).