Registration Dossier
Registration Dossier
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EC number: 203-004-2 | CAS number: 102-08-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The methode is similar to the OECD 107 guideline
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2
- pH:
- 6.5
- Remarks on result:
- other: N=8
- Type:
- log Pow
- Partition coefficient:
- 1.51
- pH:
- 12
- Remarks on result:
- other: N=4
- Conclusions:
- According to Govers H et al., log Kow of DPTU (1,3-diphenyl-2-thiourea) is about 2 at pH 6.5 and 1.51 at pH 12.
- Executive summary:
The partition coefficient of 1,3-diphenyl-2-thiourea was evaluated in a study performed according to the principles of the shake-flask method.The partition coefficient was 2 at pH = 6.5 and 1.51 at pH = 12.
Reference
Description of key information
The partition coefficient was evaluated in a study performed according to the principles of the shake-flask method.
This result is consolidated by QSAR estimations performed with OPERA (v 1.5).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.6
Additional information
The partition coefficient of 1,3-diphenyl-2-thiourea was evaluated in a study performed according to the principles of the shake-flask method.The partition coefficient was 2 at pH = 6.5 and 1.51 at pH = 12.
The partition coefficient of 1,3-diphenyl-2-thiourea was also estimated by QSAR (OPERA v1.5).The highest partition coefficient estimated is 3.6. This value is used in the risk assessment of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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