Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
204-506-4
CAS no.:
121-91-5
Index number:
Molecular formula:
C8H6O4
SMILES:
OC(=O)C1=CC(=CC=C1)C(O)=O
InChI:
InChI=1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
30
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation.

Breakdown of all 669 C&L notifications submitted to ECHA

Not Classified
Eye Irrit. 2 H319
Skin Irrit. 2 H315
STOT SE 3 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 59 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, anti-freeze products, coating products, lubricants and greases and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), production of mixtures or articles by tabletting, compression, extrusion or pelletisation and transfer of chemicals.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, for thermoplastic manufacture, as processing aid and as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones) and fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys).

This substance is used in the following products: laboratory chemicals, polymers and coating products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: rubber products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and non-industrial spraying.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, mixing in open batch processes and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, for thermoplastic manufacture, as processing aid, manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, manufacturing of the substance and formulation of mixtures.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures and for thermoplastic manufacture.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium OR3, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Italy S.R.L., Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy
  • Amcor Flexibles Valkeakoski Oy, PO Box 70 Niementie 161 37601 Valkeakoski Finland
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • Arpadis Benelux NV, Desguinlei 88A 2018 Antwerp Belgium
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • Bantam EU , Unit 19 Docklands Innovation Park 3 Dublin Ireland
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BOSTIK S.A., 420, rue d’Estienne d’Orves 92705 Colombes Cedex France France
  • Cambridge Environmental Assessments, part of RSK ADAS Europe (Ireland) Ltd, Office Suite B, Bluebell Business Centre Old Naas Rd D12XV7K Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemservice GmbH - (C8U9), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice GmbH - (D1Y0), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice GmbH - (I1T3), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Covance Clinical Development SA 172, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Dak Americas Exterior, S.L., CALENDULA 95, EDIFICIO M, OFICINA 5 28109 ALCOBENDAS MADRID/SPAIN Spain
  • Dak Americas Exterior, S.L., CALENDULA 95, EDICIFIO M, OFICINA 5 28109 ALCOBENDAS MADRID/SPAIN Spain
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DSM Coating Resins B.V., Ceintuurbaan 5 8022 AW Zwolle Netherlands
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • EQUIPOLYMERS GMBH, D-06258 D-06201 Schkopau Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • INDORAMA VENTURES QUÍMICA S.L.U., Polígono Industrial Guadarranque, 0, sin número 11360 San Roque Cádiz Spain
  • INDORAMA VENTURES QUÍMICA S.L.U., Polígono Industrial Guadarranque, 0, sin número 11360 San Roque Spain
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • Ottana Polimeri Srl, Strada Provinciale 17, Km 18, Zona Industriale 08020 Ottana Nu Italy
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • Reach Only Representative (Ireland) Ltd (shakesp), VPR House Main Street F12 FC64 Swinford County Mayo Ireland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • RHODIA OPERATIONS, 52 rue de la Haie Coq 93300 AUBERVILLIERS France
  • Ricardo Nederland BV, Catharijnesingel 33 3511 GC Utrecht Netherlands
  • Ricoh Industrie France SAS, 144 route de Rouffach F-68920 F-68920 Wettolsheim France
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • Solvay Specialty Polymers Italy S.p.A., Viale Lombardia 20 20021 BOLLATE Italy
  • STEPAN POLSKA, Urazka Street PL 56-120 Brzeg Dolny Poland
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Synthesia, a.s., Semtín103 53002 Pardubice Czech Republic
  • Synthomer Trading Limited Dutch Branch, Ijesselstraat 41 5347 KG Oss Netherlands
  • Teknor Apex BV, Mijnweg 1 Mijnweg 1, (P.O.Box 601, 6160 AP) 6167AC Geleen Please select Netherlands
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • UAB NEO GROUP, Industrijos str. 2 LT-95346 Rimkai village, Dovilai Eldership Klaipėda District Lithuania
  • Veolia PET Germany GmbH, Dierkower Damm 29 18146 Rostock Germany
  • [Confidential], [Confidential]
  • INEOS Aromatics Belgium, Amocolaan 2 2440 Geel Belgium
  • Perstorp S.p.A., Via Sempione 13 210 53 Castellanza (VA) Italy
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • Synthomer Speciality Additives AB, Durmakker 33 9940 Evergem Belgium
  • [Confidential], [Confidential]

Substance names and other identifiers

1,3-Benzenedicarboxylic acid
Other
Acide isophtalique
Other
Benzene-1,3-dicarboxylic acid
Other
IPA
Other
Isophthalate
Other
Isophthalic acid
EC Inventory, REACH pre-registration, Other, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use
isophthalic acid
REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use
Kyselina isoftalova
Other
1,3-Benzenedicarboxylic acid
Other
1,3 Benzene dicarboxylic acid
Registration dossier
1,3-Benzenedicarboxylic acid
C&L Inventory
ACIDO 1,2-BENZENDICARBOSSILICO
C&L Inventory
acido 1,3-benzenedicarbossilico
C&L Inventory
Benzene-1,2- dicarboxylic acid
C&L Inventory
Benzene-1,3- dicarboxylic acid
Registration dossier
benzene-1,3-dicarboxylate
C&L Inventory
Benzene-1,3-dicarboxylic acid
C&L Inventory, Registration dossier, Other
ISOPHTHALIC ACID
C&L Inventory, Registration dossier
ISOPHTHALIC ACID
C&L Inventory, Registration dossier
AGIC PIA
Registration dossier
Fomrez Series
Registration dossier
IPA
Registration dossier
Isophthalic acid
Registration dossier
PIA
Registration dossier
WITCOBOND SERIES
Registration dossier
121-91-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use
2088100-84-7
CAS number
Other
2088100-84-7
Deleted CAS number
Other
55185-18-7
CAS number
Other
55185-18-7
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Other (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 3 studies processed
R Melting / freezing point
345 - 384 °C @ 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
348 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.53

Vapour pressure

Study results
  • 4 studies submitted
  • 2 studies processed
R Vapour pressure
0 Pa @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
1.76 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
1.66 @ 25 °C

Water solubility

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
120 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Non-explosive (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
3.62 - 4.6 @ 25 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
8.18 - 12.27 days [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
12 days

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 2 studies submitted
  • 1 study processed
R Koc
11.86 - 79.24 L/kg [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
79.24

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 907 µg/L (2)
Intermittent releases (freshwater) 9.07 mg/L (2)
Marine water 90.7 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 16 mg/L (2)
Sediment (freshwater) 1.246 mg/kg sediment dw (2)
Sediment (marine water) 124.6 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 1.69 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 907 mg/L [2]
NOEC (4 days) 907 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 952 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 19.5 mg/L [4]
EC50 (21 days) 19.5 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (4 days) 996 - 1 000 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 617.1 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
617.1 mg/L
EC10 or NOEC for microorganisms
158.3 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.8 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 25 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.2 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 12.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.3 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 2 2
Weight of evidence 8 8 16
Other
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Dermal: 10 %

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 3 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 15 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 11.37 mg/L air (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 3
Supporting study 3 3 6
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [3]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 11 370 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOAEC (rat): 9.59 mg/m³ air [3]

Study data: inhalation
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 500 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 9.59 mg/m³ (subacute, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 9.59 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study
Weight of evidence 12 1 2
Other
Data waiving
no waivers
Study data: in vivo
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2 2 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 3
Weight of evidence 2 3 7
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed NOAEL 142 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1 1
Weight of evidence 2 4
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 2 000 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 9.07 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant