Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: 4,4'-isopropylidenediphenol
  • IUPAC name: 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
  • Other names
EC / List no.:
201-245-8
CAS no.:
80-05-7
Index number:
604-030-00-0
Molecular formula:
C15H16O2
SMILES:
CC(C)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
InChI:
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
23
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP09) approved by the European Union, this substance may damage fertility, causes serious eye damage, may cause an allergic skin reaction and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child and is toxic to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is suspected of damaging fertility or the unborn child.

Breakdown of all 1901 C&L notifications submitted to ECHA

Eye Dam. 1 H318 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Repr. 2 H361
Aquatic Chronic 2 H411
Repr. 1B H360F Harmonised Classification
Skin Sens. 1B H317
Aquatic Chronic 3 H412
STOT SE 3 H370
Asp. Tox. 1 H304
Muta. 1B H340
Carc. 1B H350
Acute Tox. 4 H302
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • R
  • Ss

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 66 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and electrical, electronic and optical equipment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, transfer of substance into small containers, mixing in open batch processes, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, treatment of articles by dipping and pouring and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: building & construction work, formulation of mixtures and/or re-packaging and scientific research and development. This substance is used for the manufacture of: plastic products, chemicals and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, closed processes with no likelihood of exposure and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, for thermoplastic manufacture and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If on skin: wash with soap and water.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M Wroclaw Sp.z.o.o., ul. Kowalska 143 51-424 Wroclaw Poland
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Italy S.R.L., Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • C.S.B. GmbH, Düsseldorfer Str. 113 47809 Krefeld Germany
  • Caplinq Europe BV, De Trompet 1126 1967 DA Heemskerk - Netherlands
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR CN_001554, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro NV, Haven 507 Scheldelaan 420 2040 Antwerpen Belgium
  • Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc., Industriestraße 3 76684 Östringen Germany
  • Cytec Engineered Materials Ltd., Abenbury Way Wrexham Industrial Estate LL13 9UZ Wrexham United Kingdom
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 173-175 D-63263 Neu-Isenburg Hesse Germany
  • ENVIGO CRS SAU 155, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Experien Chemical Services (Europe) Limited, 7 Finkle Street YO7 1DA Thirsk United Kingdom
  • Harke Services GmbH-OR3, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hexion B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Hexion B.V. OR, Seattleweg 17, Building 4 3195 ND Pernis-Rotterdam Netherlands
  • Huntsman Advanced Materials (Europe) BVBA, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BVBA OR-U, Everslaan 45 B-3078 Everberg Belgium
  • Idemitsu Chemicals Europe GmbH, Immermannstrasse 40 40210 Düsseldorf Germany
  • INEOS Composites Hispania S.L. (0341), Partida Povet, 37 ES-12580 Benicarlo Castillon de la Plana Spain
  • Kao Chemicals Europe, S.L. (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • KIST Europe Forschungsgesellschaft mbH, Campus E 71 Saarbruecken 66123 Germany
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • LG Chem Europe GmbH, Lyoner str 15, Atricom C6, D-60528 Frankfurt am Main Germany
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • NAM & NAM Europe GmbH, Emil-Figge-Str. 80 44227 Dortmund(1007) Germany
  • PPG Coatings BV, Papesteeg 102 4006 WC Tiel Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • Rondo Plast AB, Blygatan 6 27139 Ystad Sweden
  • RSI ChemRep Europe Ltd (I001), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M001), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M002), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M003), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (N001), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France
  • Solvay Specialty Polymers Italy S.p.A., Viale Lombardia 20 20021 BOLLATE Italy
  • Spolek pro chemickou a hutní výrobu, a.s., Revoluční 1930/86 400 32 Ústí nad Labem Czech Republic
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • T-NET International (EU) GmbH, Rurtal Str. 33 41849 Wassenberg NRW Germany
  • Trinseo Deutschland Anlagengesellschaft mbH, Kölner Strasse 10 65760 Eschborn Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • [Confidential], [Confidential]
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • PCC SYNTEZA SA, Szkolna 15 47-225 Kędzierzyn-Koźle opolskie Poland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • RHODIA OPERATIONS - 1, 40 rue de la Haie Coq 93306 Aubervilliers France
  • Team-Trade, s.r.o., Rybničná 18/1 16200 Prague Czech Republic

Other names

  • -
  • 2,2-Bis(4-hydroxyphenyl) propane
  • 2,2-Bis(4-hydroxyphenyl)propane
  • 2.2-bis(4-hydroxyphenyl)propane
  • 4,4' isopropylidenediphenol
  • 4,4'-(1-Methylethyliden)bisphenol
  • 4,4'-(propane-2,2-diyl)diphenol
  • 4,4'-dihydroxy-2,2-diphenylpropane
  • 4,4'-Isopropylidendiphenol
  • 4,4'-Isopropylidenebisphenol
  • 4,4'-ISOPROPYLIDENEDIPHENOL
  • 4,4'-isopropylidenediphenol (Bisphenol-A)
  • 4,4'-isopropylidenediphenol (CAS 80-05-7)
  • 4,4'-isopropylidenediphenolbisphenol A
  • 4,4'-Propane-2,2-diyldiphenol
  • 4,4-isopropylidenediphenol
  • 4,4`-isopropylidenediphenol
  • 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
  • Bisphenol A
  • bisphenol A 4,4'-isopropylidenediphenol
  • bisphenol A; 4,4'-isopropylidenediphenol
  • Bisphenol-A
  • Diphenylpropane, Bisphenol-A
  • Phenol, 4,4 -(1-methylethylidene)bis-
  • Phenol, 4,4'-(1-methylethylidene)bis-
  • Phenol, 4,4'-isopropylidenedi-
  • 4,4'-isopropylidenediphenol
  • 4,4'-isopropylidenediphenol (Bisphenol A; BPA)
  • 4,4’-isopropylidenediphenol (Bisphenol A; BPA)
  • bisphenol A (Bisphenol A; BPA)
  • 4,4'-(1-Methylethylidene)bisphenol
  • 4,4'-Bisphenol A
  • 4,4'-Isopropylidendiphenol
  • 4,4'-Isopropylidenediphenol
  • Bispenol- A
  • Bisphenol
  • Bisphenol A
  • Bisphenol A - Polycarbonate grade
  • Bisphenol A ER grade - Flake
  • BPA
  • Diphenol methylethylidene
  • Diphenylol propane
  • DPP
  • p,p'-Bisphenol A
  • p,p'-Dihydroxydiphenylpropane
  • p,p'-Isopropylidenebisphenol
  • p,p'-Isopropylidenediphenol
  • PARABIS(R) Resin intermediate
  • Bisphenol A
  • BPA

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Other (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 1 study processed
R Melting / freezing point
154 - 156.5 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
155 °C

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
250 - 360 °C @ 17 - 1 013 hPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
360 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Density
1.2 g/cm³ @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.2

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0 - 0 Pa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
3.4 @ 21.5 °C and pH 6.4 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.4 @ 21.5 °C

Water solubility

Study results
  • 6 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
298 - 318 mg/L @ 25 °C and pH 7 - 8 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
300 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 1 study processed
R Flash point
227 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
227 °C

Auto flammability

Study results
  • 4 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
510 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
510 °C

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
11.3 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
11.3

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
3.12 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
3.12 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 3 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
17.4 - 235 h [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
12 h

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 10 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
73 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other 4 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
750

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 7 studies submitted
  • 3 studies processed
% Distribution in Media:
R Air 0 - 0.01 % [3]
R Water 30.5 - 32.9 % [3]
R Soil 65.3 - 67.9 % [3]
R Sediment 1.51 - 1.8 % [3]
R Suspended sediment 0.05 % [1]
R Biota 0 % [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 18 µg/L (1)
Intermittent releases (freshwater) 11 µg/L (1)
Marine water 18 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 320 mg/L (1)
Sediment (freshwater) 1.2 mg/kg sediment dw (1)
Sediment (marine water) 240 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 3.7 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 12 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 4.6 - 11 mg/L [4]
NOEC (14 days) 3.2 mg/L [1]
NOEC (4 days) 2.26 - 2.28 mg/L [2]
LOEC (14 days) 10.15 mg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
4.6 mg/L
LC50 for marine water fish
9.4 mg/L

Long–term toxicity to fish

Study results
  • 20 studies submitted
  • 4 studies processed
P/RResults
NOEC (1.216 years) 16 µg/L [1]
NOEC (5.467 months) 160 µg/L [1]
NOEC (3.867 months) 66 - 250 µg/L [8]
NOEC (55 days) 250 µg/L [2]
NOEC (36 days) 640 µg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study 7
Weight of evidence
Other 9
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
16 µg/L
EC10 / LC10 or NOEC for marine water fish
66 µg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 20 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 1.1 mg/L [1]
EC50 (48 h) 10.2 mg/L [1]
NOEC (4 days) 510 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 10
Weight of evidence
Other 8
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
10.2 mg/L
EC50 / LC50 for marine invertebrates
1.1 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 17 studies submitted
  • 4 studies processed
P/RResults
NOEC (10.933 months) 25 µg/L [1]
NOEC (28 days) 170 - 370 µg/L [3]
NOEC (21 days) 3.16 mg/L [1]
NOEC (48 h) 1.8 mg/L [1]
LOEC (10.933 months) 640 µg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study 5
Weight of evidence
Other 8
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
25 µg/L
EC10 / LC10 or NOEC for marine invertebrates
170 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 1.1 - 3.1 mg/L [3]
EC10 (4 days) 400 - 1 360 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
2.73 mg/L
EC50 for marine water algae
1.1 mg/L
EC10 or NOEC for freshwater algae
1.36 mg/L
EC10 or NOEC for marine water algae
400 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 20 - 32 mg/L [3]
NOEC (7 days) 7.8 mg/L [1]
LOEC (7 days) 20 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
20 mg/L
EC10 or NOEC for freshwater plants
7.8 mg/L

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
IC50 (16 h) 54.5 mg/L [1]
EC10 (18 h) 320 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
320 mg/L

Sediment toxicity

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 12 - 54 mg/kg sediment dw [4]
LOEC (28 days) 32 - 110 mg/kg sediment dw [4]
EC50 (28 days) 57 - 210 mg/kg sediment dw [3]
LC50 (28 h) 38 - 54 mg/kg sediment dw [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
12 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 100 mg/kg soil dw [1]
LC50 (28 days) 100 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 8
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 500 mg/kg soil dw [1]
LOEC (28 days) 1 g/kg soil dw [1]
LC50 (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
500 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 20 - 320 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
20 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 8 studies submitted
  • 1 study processed
P/RResults
NOEC (63 days) 1 000 mg/kg bw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 2 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg food

Toxicity to mammals

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 2 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 2 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 31 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 31 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 1 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 1 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.9 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 1.9 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 4 µg/kg bw/day repeated dose toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 15 2
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 30 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
approx. LD50 2 000 - 5 000 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 3 000 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 4 100 mg/kg bw
Inhalation route:
Adverse effect observed Discriminating conc. 170 mg/m³
Dermal route:
Adverse effect observed LD50 3 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 750 ppm [2]
NOAEL (mouse): 300 ppm [2]
LOAEL (rat): 600 mg/kg bw/day [1]
NOEL (rat): 75 ppm [1]
NOEL (mouse): 30 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (rat): 10 mg/m³ air [1]
LOEC (rat): 10 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 50 mg/kg bw/day (subchronic, mouse)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 150 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 10 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 11
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: other studies
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 13
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 50 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 640 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 164 mg/kg bw/day (subchronic, rat)

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant