Registration Dossier
Registration Dossier
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EC number: 203-372-4 | CAS number: 106-20-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Bis(2-ethylhexyl)amine
- EC Number:
- 203-372-4
- EC Name:
- Bis(2-ethylhexyl)amine
- Cas Number:
- 106-20-7
- Molecular formula:
- C16H35N
- IUPAC Name:
- bis(2-ethylhexyl)amine
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 956 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: = 1190 µL/kg bw (calculation of the dose in mg/kg bw by means of the density at 20°C: 0.803 g/cm³)
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Any other information on results incl. tables
Of pronounced toxicity after a short term skin contact.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The study on acute dermal toxicity of bis(2-ethylhexyl)amine in rabbits resulted in a LD50 value of 956 mg/kg bw. No further information given. A classification according to the CLP Regulation (EC) No. 1272/2008 (EU-GHS: Cat. 3) is required.
- Executive summary:
A dermal LD50 value of 1.19 mL/kg, equivalent to 956 mg/kg bw, was reported for rabbits, with no further details, because data were only available as secondary quotation cited in RTECS updates 9504 and 199709 (Union Carbide 1968; reliability score 4).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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