Registration Dossier
Registration Dossier
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EC number: 231-569-5 | CAS number: 7637-07-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity value for boron for flannelmouth sucker was estimated at 125 mgB/l and was on the lower end of the wide range reported in the literature.
Key value for chemical safety assessment
Additional information
The most reliable tests of acute effects on fish (4 day duration) show mortality effects (LC50) in the range of 125 to 600 mg-B/L. These include salmonids (Oncorhynchus kisutch, O. tshawtscha) and several endangered species (Gila elegans, Ptychocheilus lucia, Xyrauchen texanus, and Catostomas latipinnis). Juveniles and fry appear to be the most sensitive fish life-stage (Hamilton, 1995; Hamilton and Buhl, 1990).
A few studies reported endpoints in the 5 to 15 mg-B/L range, but these were judged not reliable, or did not have sufficient information to permit data quality review. For example, Turnbull et al. (1954) reported a 24-hour TLm to bluegill of 4.6 mg-B/L in response to the test substance sodium tetraborate decahydrate. However, they also reported a 24-hour TLm of 2389 mg-B/L in response to the test substance boron trifluoride. Their procedure used relatively large fish (ca. 5 g, 7 cm). No information was provided on replication, intervals between test concentrations, or similar operational details. Guhl (1992a) reported 96-hour LC50 for zebrafish of 14.2 mg-B/L, but cited an unpublished study from Henkel KGaA. Terhaar et al. (1976) reported median lethal times for boric acid of 10 hours, exposed to 1750 mg-B/L which was extrapolated to an acute toxicity estimate of 17.5 to 175 mg-B/L. These studies cannot be adequately reviewed or compared to standard protocols, thus they cannot be judged reliable.
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