Registration Dossier
Registration Dossier
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EC number: 950-480-9 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety assessment of Brown Algae-derived Ingredients as Used in Cosmetics
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 019
- Bibliographic source:
- http://online.personalcarecouncil.org
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- An in vivo test is available in literature.
Test material
- Reference substance name:
- Ascophyllum nodosum, ext.
- EC Number:
- 283-907-6
- EC Name:
- Ascophyllum nodosum, ext.
- Cas Number:
- 84775-78-0
- Molecular formula:
- Not applicable; a generic molecular formula cannot be provided for this UVCB substance.
- IUPAC Name:
- Ascophyllum nodosum, extract
- Details on test material:
- - Name of test material (as cited in study report): Algea Fert Solid K+
- Substance type: fertilizer ( algal extract)
- Physical state: solid, black micro-flakes
- Lot/batch No.: 00680
- Expiration date of the lot/batch: March 2012
- Stability under test conditions: Stable under suitable storage conditions.
- Storage condition of test material: original tightly-closed containers in well- ventilated place.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- 20 test and 10 control guinea pigs
- Details on study design:
- Concentration 0.1 to 400 μL of 25% to 75% water solution.
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test test item was non-sensitising.
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