Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-660-8 | CAS number: 26401-35-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The sensitising potential of diisotridecyl adipate was tested in two independent human repeated insult patch tests (RL2). In both tests, diisotridecyl adipate was demonstrated not to be sensitising.
The dermal sensitisation potential of diisotridecyl adipate was tested with human volunteers using a repeated insult patch test. 104 human subjects (19 males and 85 females) were divided into two groups (49 and 55 subjects) for semi-occlusive and occlusive application of test patches.
Induction exposure consisted of nine repeated 24 h exposures at the same site (left upper back). Test substance was administered on saturated patches (0.2 mL test substance) on Monday, Wednesday, and Friday for 3 weeks followed by a rest period of 2 weeks. After a single challenge exposure (24 h) on a virgin patch site (upper right back), the challenge reaction was evaluated 24, 48, and 72 hours after patch application.
No skin reaction in any of the 104 test subjects was observed either during induction exposure nor at any of the challenge readings.
In this study, diisotridecyl adipate did not exhibit any dermal sensitizing potential in humans (Zimmermann/Mobil/HRL 1,987).
The second test was performed using to the same method. A similar result was obtained.
The read-across substance diethylhexyl adipate was in a guinea pig test not sensitising.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data have been located.
Justification for classification or non-classification
In two human repeated insult patch tests, diisotridecyl adipate was demonstrated to be not sensitizing. According to EU Regulations (Directive 67/548/EEC and Regulation (EC) No 1272/2008), classification is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
