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Diss Factsheets
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EC number: 247-660-8 | CAS number: 26401-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (abdominal area as test site, for half of the animals abrasion of skin prior to test substance application, occlusive wrapping, limited reporting)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- ; abdominal area as test site, for half of the animals abrasion of skin prior to test substance application, occlusive wrapping, limited reporting
- Principles of method if other than guideline:
- No guideline stated in report, but method used is similar to OECD TG 402
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diisotridecyl adipate
- EC Number:
- 247-660-8
- EC Name:
- Diisotridecyl adipate
- Cas Number:
- 26401-35-4
- Molecular formula:
- C32H62O4
- IUPAC Name:
- diisotridecyl adipate (DITA)
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): diisotridecyl adipate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: abdominal area; size not reported
- % coverage: no data
- Type of wrap if used: impervious material
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rabbits skin was cleansed
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 (sex not specified)
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: limit test, 5000 mg/kg bw is the only dose tested
- Mortality:
- no mortalities were observed (0/10 animals)
- Clinical signs:
- other: Diarrhea (4 animals, various days between day 4 and 14) Emaciation (2 animals, days 6 through 14) Lethargy (1 animal, days 9 through 14) Abdomen bloated (1 animal, days 13 and 14)
- Gross pathology:
- no data
- Other findings:
- - Other observations: at the end of exposure, erythema scores were 1 or 2 for 9 animals. One animals showed a score of 0. Edema was noted in 3 animals (score 1 or 2).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity test (only 1 dose, limit test), diisotridecyl adipate did not cause any mortality at a dose of 5000 mg/kg bw. Diisotridecyl adipate is not to be classified according to EU regulations.
- Executive summary:
The acute dermal toxicity of diisotridecyl adipate was determined in 10 New Zealand White rabbits each receiving a single dose of 5000 mg/kg bw of test substance (limit test). The exposure time was 24 hours followed by an observation period of 14 days. Before application of test substance, the clipped skin of half of the test animals was abraded. At the end of the exposure period, the skin was cleansed.
No mortality was observed during the test. Two animals showed signs of emaciation. Other clinical observations were diarrhea (4 animals), and in single animals lethargy and bloated abdomen. Body weight development was below normal.
The acute dermal LD50 was determined to be > 5000 mg/kg bw in rats (Moreno/Mobil 1978b).
Overall, the study was conducted similar to OECD test guideline 402 with some restrictions (abdominal area as test site, abrasion of skin prior to test substance application, occlusive wrapping, limited reporting).
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