Sodium O-isobutyl dithiocarbonate

Endpoint summary

Additional information

No studies were available for assessing the genotoxicity of Sodium isobutyl xanthate or other xanthates.

The results should be considered together with the results of test with the 3 assays from FDA genetic toxicity set, designed from the FDA archives and openly published results of genetic toxicity tests date for:

Bacterial gene mutation in vitro

• The Microbial composite (Sal_Ecoli_Bac) (A7A,3644 records)
• TheSalmonella typhimurium5 strains (A7B, 3535 records)
• The E.coli composite (A7C, 527 records)
• The E.coli WP strains (A7D, 280 records)

Mammalian gene mutationin vitro

• The Mammalianin vitroCHO V79 hgprt loci (A7O, 617 records)
• The Mammalianin vitroML5178y tk loci Ct (A7N, 806 records)
• The Mammalianin vitroML5178y tk loci A (AN7, 565 records)
• The Mammalianin vitroML5178y tk loci B (AN8, 563 records)

The Chromosomal aberrationsin vitro

• The Chromosomal Absin vitrocomposite (A7U, 1385 records)
• The Chromosomal Absin vitroCHO cells (A7V, 686 records)
• The Chromosomal Absin vitrocells (A7W, 744 records)
• The Chromosomal Absin vitroHuLym (A7X, 187 records)
• The Chromosome Absin vitroUndefined cells (A8H, 280 records)

 

The results of tests with the FDA GeneTOX sets are summarized in the following tables.

 

Important notice:The RCA method expert call is a computer-generated output that is considered, along with other available information, in formulating the final conclusion.The Final Conclusion is a conclusion made by the reviewer, taking into account all the available evidence, including thein-silicoand available experimental results.

Table 1. Ames test

Compound	A7A	A7B	A7C	A7D	RCA Method Expert Call (Overall)	Review expert
O-ethyl dithiocarbonic acid	-	-	-	-	-*	-

 

Table 2. Mammalian gene mutationin vitro

Compound	A7O	A7N	AN7	AN8	RCA Method Expert Call (Overall)	Review expert
O-ethyl dithiocarbonic acid	-	-	-	-	-*	-

 

Table 3. The Chromosomal aberrationsin vitro

Compound	A7U	A7V	A7W	A7X	A8H	RCA Method Expert Call (Overall)	Review expert
O-ethyl dithiocarbonic acid	-	-	-	-	-	-*	-

 

 

Table4.  Summary of results and overall conclusions for the genotoxicity tests

Compound	Ames		MAin vitro		CAin vitro		FINAL CONCLUSION
	RCAMethod Expert Call	Review Expert	RCAMethod Expert Call	Review Expert	RCAMethod Expert Call	Review Expert
O-ethyl dithiocarbonic acid	-*	-	-*	-	-*	-	-

AMES= bacterial mutation assay; MA = mammalian; CA = chromosomal aberration;

+ positive; (+) potentially positive; - negative; (-) potentially negative. ? –inconclusive * possible structural coverage problems

 

The RCA paradigm, implemented in the RCA decision support system, requires the following criteria for a chemical to be designated as POSITIVE:

1.     To be active in more than one test assay within a test battery

2.     To be active in a test assay, there must be two or more structurally similar fragments across the modules of the test assay.

Tables 1 - 4 reveal these conditions were not met by test compound in FDA Genetic Toxicity Set. The unknown structural features, which were detected in all test batteries, are typical for xantate moieties.

The xantates were not reported a genetoxic in publicly available sources and no component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by. The tested substance was reported in NICNAS Priority existing chemical assessment report (1995, Vol.6, 66p) and it was not listed there as genetic toxicant for humans. The Final conclusion is that the tested chemical is considered to be nonthreatening to humans from this evaluation.

 

The tested molecule does not contain any confirmed alerts and is assumed to be inactive.

The probability that the prediction is accurate is 80%.

 

Other (Q)SAR predictions of:

Lazar Toxicity Predictions: Mutagenicity-Salmonella typhimurium (CPDB) and

 

Tox Predictfor:(http://apps.ideaconsult.net:8080/ToxPredict)

The above QSAR software models indicate that sodium isobutyl xanthate (CAS# 140-90-9) and other xanthates are inactive as a mutagenic substance and does not contain alert structures according to Benigni/Bossa rules.

Justification for selection of genetic toxicity endpoint
The Final conclusion is that the tested chemical is considered to be nonthreatening to humans from this evaluation.

Endpoint Conclusion: No adverse effect observed (negative)