Registration Dossier
Registration Dossier
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EC number: 231-195-2 | CAS number: 7446-09-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: in vitro study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Entry adopted from the OECD SIAR on sulfur dioxide without modification.Study meets generally accepted scientific principles, well documented, specific investigation of mechanism of bronchoconstriction - in vitro study; study acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sulfur dioxide and sodium metabisulfite induce bronchoconstriction in the isolated perfused and ventilated guinea pig lung via stimulation of capsaicin-sensitive sensory nerves
- Author:
- Bannenberg G, Atzori L, Xue J, Auberson S, Kimland M
- Year:
- 1 994
- Bibliographic source:
- Respiration 61: 130-137
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study only reports on isolated mechanistic investigations:
Mechanism of bronchoconstriction - in vitro study. - GLP compliance:
- no
Test material
- Reference substance name:
- Sulphur dioxide
- EC Number:
- 231-195-2
- EC Name:
- Sulphur dioxide
- Cas Number:
- 7446-09-5
- Molecular formula:
- SO2
- IUPAC Name:
- Sulphur dioxide generated from sulphur by combustion
- Details on test material:
- - Name of test material (as cited in study report): sulphur dioxide
- Physical state: gaseous
no further details stated
Constituent 1
Results and discussion
Any other information on results incl. tables
Lungs of capsaicin-pretreated guinea pigs showed decreased sulphur dioxide-induced bronchoconstriction. Release of CGRP neuropeptide: significantly increased from start to termination of exposure; no release from lungs of capsaicin-pretreated guinea pigs.
Bronchoconstriction, induced in isolated guinea pig lung by in vitro exposure to 250 ppm sulphur dioxide, was accompanied by the release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive sensory nerves into the pulmonary circulation.
Applicant's summary and conclusion
- Conclusions:
- Bronchoconstriction, induced in isolated guinea pig lung byin vitro exposure to 250 ppm sulfur dioxide, was accompanied by the release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive sensory nerves into the pulmonary circulation.
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