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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study according OECD 404 and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl alcohol
EC Number:
202-859-9
EC Name:
Benzyl alcohol
Cas Number:
100-51-6
Molecular formula:
C7H8O
IUPAC Name:
phenylmethanol
Details on test material:
- Name of test material (as cited in study report): Benzylalkohol
- Purity: 99.99%
- Appearance: colourless liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Strain: albino rabbits, HC:NZW
- Source: Interfauna U.K. Ltd., Wyton, Huntingdon, England, UK
- Age at study initiation: adult rabbits
- Weight at study initiation: 3.1-3.4 kg
- Housing: individually under standardized conventional conditions in stainless steel cages with perforated floors
- Diet: approx. 100-120 g/animal and day; feeding once per day in the morning
- Water: ad libitum
- Acclimation period: at least 14 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3
- Humidity (%): approx. 50
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: the opposite dorsal area of the trunk of each animal served as control
Amount / concentration applied:
500 µl (ca. 522 µg)
Duration of treatment / exposure:
4 hours
Observation period:
7 days (all changes had completely subsided after 7 days)
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: dorso-lateral area of the trunk, 6x6 cm
The test compound was applied to a hypoallergenic patch and a further patch was moistened with water for control; they were loosely held in contact with skin by means of a semiocclusive dressing for the exposure period

REMOVAL OF TEST SUBSTANCE
- Washing (if done): carefully with water
- Time after start of exposure: 4 h

SCORING SYSTEM:
The degrees of erythema/eschar formation and oedma formation was recorded as specified by Draize.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1, #2
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48, 72 hours
Score:
>= 0 - <= 1
Max. score:
4
Reversibility:
fully reversible within: 72 hours
Remarks on result:
other: mean score: 0.7
Irritation parameter:
edema score
Basis:
animal: #1, #2, #3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Irritant / corrosive response data:
see data above
Other effects:
no further data

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Executive summary:

In a study for skin irritation/corrosion on rabbits according to OECD TG 404 benzyl alcohol showed only slight effects to the skin in one animal (exposure period: 4 hours, 2 rabbits without any irritant effects, 1 rabbit with erythema score 1 at maximum, fully resolved within 72 hours) (Bayer AG 1990).