Registration Dossier
Registration Dossier
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EC number: 270-128-1 | CAS number: 68411-46-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP (performed 1988), only summary report, acceptable because no mortality occured
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Body weight not controlled. No information on housing conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene
- EC Number:
- 270-128-1
- EC Name:
- Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene
- Cas Number:
- 68411-46-1
- Molecular formula:
- C16H19N - C28H43N (main constituents)
- IUPAC Name:
- Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): TK 12340
- Lot/batch No.: EN-127 506.82
Constituent 1
- Specific details on test material used for the study:
- - Lot/batch No.: EN-127 506.82
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Piloerection, abnormal body positions, and dyspnea were seen, being common symptoms in acute toxicity testing. The animals recovered within 9 days.
- Gross pathology:
- No adverse findings noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance caused no mortality when administered dermally at a single dose of 2000 mg/kg bw to the albino rat.
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