Nickel bis(dihydrogen phosphate)

GHS

General Information

Implementation:

EU

Type of classification:

harmonised classification

Remarks:

• Legal classification and labelling according to Regulation 1272/2008/EC annex VI Table 3.1, 1st ATP


• Self-classification - Substance contains approximately < 11 % phosphoric acid and pH of <2, which warrants more stringent classifications for skin corrosion and eye damage: Skin Corrosion 1B (H314) and Eye Damage 1 (H318)


• Self-classification based on read-across from nickel sulphate - Acute toxicity 4 (oral; H302), Acute toxicity 4 (inhalation; H332), Repro 1B (H360), and Muta 2 (H341).


• In addition, a comprehensive read-across assessment was recently completed based on bioaccessibility data in synthetic lung fluids of various nickel compounds combined in vivo verification data for three source nickel substances. The bioaccessibility-based paradigm presented in a summary document in Section 7.2.2 and Appendix B2 of the CSR enables grouping of target Ni substances for classification purposes according to bioaccessibility in interstitial fluid as demonstrated. The outcome of this assessment indicates that Ni bis(dihydrogen phosphate) should be read-across from Ni sulphate for acute oral and inhalation toxicity. Therefore, application of this read-across paradigm suggests that Ni bis(dihydrogen phosphate) should be classified as Acute Tox 4.; H302 and H332. Classifications based on read-across are reflectetd in this dossier.

 

Related composition

Related composition:

Nickel bis(dihydrogen phosphate)

Nickel bis(dihydrogen phosphate) - LE composition 1

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 4

Hazard statement:

H302: Harmful if swallowed.

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Hazard category:

Acute Tox. 4

Hazard statement:

H332: Harmful if inhaled.

Skin corrosion / irritation

Hazard category:

Skin Corr. 1B

Hazard statement:

H314: Causes severe skin burns and eye damage.

Serious eye damage / eye irritation

Hazard category:

Eye Damage 1

Hazard statement:

H318: Causes serious eye damage.

Respiratory sensitisation

Hazard category:

Resp. Sens. 1

Hazard statement:

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin sensitisation

Hazard category:

Skin Sens. 1

Hazard statement:

H317: May cause an allergic skin reaction.

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Hazard category:

Repr. 1B

Hazard statement:

H360: May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Specific effect:

Perinatal mortality

Effects on or via lactation

Reason for no classification:

data conclusive but not sufficient for classification

Germ cell mutagenicity

Hazard category:

Muta. 2

Hazard statement:

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Carcinogenicity

Hazard category:

Carc. 1A

Hazard statement:

H350i: May cause cancer by inhalation.

Route of exposure:

inhalation

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Hazard category:

STOT Rep. Exp. 1

Hazard statement:

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Affected organs:

other: Respiratory tract only

Route of exposure:

inhalation

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

1

M-Factor chronic:

1

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Danger

Hazard pictogram

GHS05: corrosion

GHS07: exclamation mark

GHS08: health hazard

GHS09: environment

Hazard statements

H302: Harmful if swallowed.

H314: Causes severe skin burns and eye damage.

H317: May cause an allergic skin reaction.

H318: Causes serious eye damage.

H332: Harmful if inhaled.

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H350i: May cause cancer by inhalation.

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H360D: May damage the unborn child.

Perinatal mortality

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H410: Very toxic to aquatic life with long lasting effects.

Notes

Note H