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EC number: 229-355-1
CAS number: 6486-23-3
The test item was assessed for its possible contact allergenic potential
in a local lymph node assay according to OECD TG 429. The test was
performed using test item concentrations of 5, 10 and 20% (w/v). The
animals (5 female mice/dose group) did not show any clinical signs
during the course of the study and no cases of mortality were observed.
In this study Stimulation Indices (S.I.) of 1.4, 1.6 and 1.9 were
determined with the test item at concentrations of 5, 10 and 20% (w/v)
in DMSO, respectively. The results obtained with the positive control
confirmed the validity of the test. The test item was not a skin
sensitiser under the conditions tested.
The animals did not show any clinical signs during the course of the
study and no cases of mortality were observed. Due to the intense yellow
colour of the test item local irritation reactions such as ear redness
could not be detected. The body weight of the animals was within the
normal range. Calculation of the EC3 value was not performed, because no
test concentration produced a SI of 3 or higher.
The test item did not caus skin sensitisation in a LLNA study.
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