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Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 Nov 2020 - 11 Nov 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
According to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
DIN EN 17199-3:2019-12 “Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
1 measurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). The relative humidity of the test atmosphere was 48%. 182.2 g (630.4 cm³) test material was used for the measurement, at a dosing rate of 18.2 g/min. 1 measurement was performed for background and sample, with a measurement duration of 3 and 10 minutes, respecitvely.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(4-chloro-2-nitrophenyl)azo]-N-(2-chlorophenyl)-3-oxobutyramide
EC Number:
229-355-1
EC Name:
2-[(4-chloro-2-nitrophenyl)azo]-N-(2-chlorophenyl)-3-oxobutyramide
Cas Number:
6486-23-3
Molecular formula:
C16H12Cl2N4O4
IUPAC Name:
2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-chlorophenyl)-3-oxobutanamide
Test material form:
solid: nanoform, no surface treatment

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
46 281.3 other: particles/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
15 910.3 other: particles/cm³
Remarks on result:
other: number of airborne nanoparticles per cm³, size range 10-100 nm

Any other information on results incl. tables

The cleaned, almost particle-free air had a total particle count of 5 particles/cm³ in the range of 10 nm – 417 nm, whereby the nanoscale fraction (10 - 100 nm) contained 3 particles/cm³.

Summary SMPS result:

Range

[nm]

Mean

[nm]

 

Concentration

[ particles /cm³]

I(CD)

[particles/mg]

 

E(CD)

[1/mg·s]

 10 -100

 47.0

 15910.3

 46281.3

 77.1

 100 - 417

 159.9

 2512.2

 7307.4

 12.2

 10 - 417  62.4  18422.4 53588.7  89.3 

Summary OPS result:

Range

[µm]

Mean

[µm]

 

Concentration

[ particles /cm³]

I(CD)

[particles/mg]

 

E(CD)

[1/mg·s]

 0.3 - 10

 5.6

 337.9

 982.8

 1.6

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199-3:2019-12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by clean, almost particle-free air.

The SMPS counted 15910.3 particles in the nanoscale (10 - 100 nm) per cm³, corresponding to a dustiness index of 46281.3 particles in the nanoscale (10 - 100 nm) per mg. The particle number in the whole SMPS size range (10-417 nm) was 18422.4 per cm³, corresponding to a dustiness index of 53588.7 particles/mg (size 10 - 417 nm).

The mean size of the nanoparticles was 47.0 nm, the mean size of particles in the range 10 - 417 nm was 62.4.

The OPS (0.3 - 10 µm) counted 337.9 particles per cm³ corresponding to a dustiness index of 982.8 particles per mg. The mean size of the particles was 1.6 µm.