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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
other: skin irritation study
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
EC Number:
221-374-3
EC Name:
N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
Cas Number:
3081-01-4
Molecular formula:
C19H26N2
IUPAC Name:
N1-(5-methylhexan-2-yl)-N4-phenylbenzene-1,4-diamine
Details on test material:
Santoflex 14

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact and abraded skin
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 h
Observation period:
7 days
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
8
Reversibility:
other: 48 h were not evaluated; at 24 h and 72 h no skin irritation observed
Remarks on result:
other: slight defatting effect
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
8
Reversibility:
other: 48 h were not evaluated; at 24 h and 72 h, no details on erythema score given, however, no skin irritation observed
Remarks on result:
other: slight defatting effect
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
8
Reversibility:
other: 48 h were not evaluated; at 24 h and 72 h no details on edema score given, however, no skin irritation observed
Remarks on result:
other: slight defatting effect

Any other information on results incl. tables

slight defatting effect, skin flaked off in seven to ten days. No injury in deph.

Applicant's summary and conclusion

Interpretation of results:
not irritating