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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study report does not give sufficient experimental details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Principles of method if other than guideline:
other: acute inhalation toxicity study
GLP compliance:
no
Test type:
other: acute inhalation toxicity study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Santoflex 14

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
6 h
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Average temoerature inside chamber: 76.5°F

Average relative humidity inside chamber: 60.0 %

Amount of sample to start: 100 g

revovered: 99.8 g

vaporized or left: 0.2 g( 0.2%)

Mortality: none

All animals survived the six hour exposure as well as the following ten day observation period.

Clinical signs: Some discomfort developed during exposure but there was no weakness of consequence. Nasal and ocular mucosae remained free of inflammation. Occasional irregular breathing was noted. Behavior appeared normal in 24 -hours. The ten day observation period was uneventful.

Applicant's summary and conclusion