Registration Dossier
Registration Dossier
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EC number: 221-374-3 | CAS number: 3081-01-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
- EC Number:
- 221-374-3
- EC Name:
- N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
- Cas Number:
- 3081-01-4
- Molecular formula:
- C19H26N2
- IUPAC Name:
- N1-(5-methylhexan-2-yl)-N4-phenylbenzene-1,4-diamine
- Details on test material:
- Santoflex 14
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1260, 1580, 2000, 2510, 3160 mg/kg
- No. of animals per sex per dose:
- combined (male/females): 5 per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 100 mg/kg bw
- 95% CL:
- 2 000 - 2 200
- Remarks on result:
- other: clinical signs: reduced appetide and activivty (survivors), increasing weakness, collapse and death (decedents),; gross autopsy: vicera appeared normal (survivors), hemorrhagic areas of the lung, liver discoloration, acute gastrointestinal inflammation
Any other information on results incl. tables
Mortality:
time to mortality: one to four days after application
1260 mg/kg bw: 0/3 males, 1/2 females, combined: 1/5
1589 mg/kg bw: 0/2 males, 2/3 females, combined: 2/5
2000 mg/kg bw: 0/3 males, 2/2 females, combined 2/5
2510 mg/kg bw: 0/2 males, 3/3 females, combinded 3/5
3160 mg/kg bw: 2/3 males, 2/2 females, combinded 4/5
Signs of intoxication: reduced appetite and activity (two to four days in survivors), increasing weakness, collapse and death.
Gross autopsy decedents: hemorrhagic areas of the lung, liver discoloration, and acute gastrointestinal inflammation
Survivors (7 days): vicera appeared normal
Applicant's summary and conclusion
- Executive summary:
LD50 rat: 2100 mg/kg bw
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