Registration Dossier
Registration Dossier
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EC number: 500-002-6 | CAS number: 9002-92-0 1 - 2.5 moles ethoxylated
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two toxicity to micro-organism studies as-
2. and 3. - GLP compliance:
- not specified
- Analytical monitoring:
- no
- Remarks:
- 2. no data available, 3. no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge
- Details on inoculum:
- 2.
- Concentration: 1527 mg/l
3.
- Laboratory culture: Test organism municipal activated sludge was obtained from laboratory wastewater treatment plant. - Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 140 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: 2.
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- 750 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: 3.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:
Toxicity to activated sludge study was carried out. The study was performed according to EC Guideline 88/302/EC. Inoculum conc. used for the study was 1527 mg/l. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the EC50 value was determined to be 140 mg/l.
Another toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. Test chemical concentration was not verified analytically. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the 30 mins EC20 value was determined to be 750 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 140 mg/L
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:
Toxicity to activated sludge study was carried out. The study was performed according to EC Guideline 88/302/EC. Inoculum conc. used for the study was 1527 mg/l. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the EC50 value was determined to be 140 mg/l.
Another toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. Test chemical concentration was not verified analytically. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the 30 mins EC20 value was determined to be 750 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
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