Registration Dossier
Registration Dossier
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EC number: 247-477-3 | CAS number: 26140-60-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic toxic effects of polyphenyl mixtures
- Author:
- Young G, Petkau A, Hoogstraten J
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, Volume 30, Issue 1, pp 7-19
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Santowax OM
- IUPAC Name:
- Santowax OM
- Reference substance name:
- Terphenyl
- EC Number:
- 247-477-3
- EC Name:
- Terphenyl
- Cas Number:
- 26140-60-3
- Molecular formula:
- C18H14
- IUPAC Name:
- 2-phenyl-1,1'-biphenyl; 3-phenyl-1,1'-biphenyl; 4-phenyl-1,1'-biphenyl
- Details on test material:
- Santowax OM is a commercial organic coolant containing 4.7% biphenyl, 64.1 % o-terphenyl, 24% m-terphenyl and 6.1% p-terphenyl.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: feed
- Frequency of treatment:
- daily
- Details on study design:
- daily dietary intake of 350 mg/kg
Results and discussion
Results of examinations
- Details on results:
- at 350 mg/kg bw, irreversible interstitial nephritis with scarring was observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
After daily intake of 350 mg/kg (or more) Santowax OM (wich is a mixture of mainly ortho- and meta- terphenyl), used as a coolant, severe and to some extent irreversible chemical nephrosis and interstitial nephritis was found in rats following prolonged ingestion.
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