N-[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine

Guidance on Safe Use

First-aid measures

Description of first aid measures
If inhaled: If breathed in, move person into fresh air.
                Artificial respiration and/or oxygen may be necessary.
                Call a physician immediately.
In case of skin contact: Take off contaminated clothing and shoes immediately.
                                   Wash off with soap and water.
                                   Call a physician immediately.
In case of eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
                                  Remove contact lenses.
                                  If eye irritation persists, consult a specialist.
If swallowed: If swallowed, rinse mouth with water (only if the person is conscious).
                    Call a physician immediately.

Most important symptoms and effects, both acute and delayed 

Risks: No information available.

Indication of any immediate medical attention and special treatment needed
Treatment: Treat symptomatically

Fire-fighting measures

Extinguishing media

Suitable extinguishing media: Water mist,  Dry powder, Foam, Carbon dioxide (CO2), Sand, Aqueous film forming foam (AFFF).
Use extinguishing measures that are appropriate to localcircumstances and the surrounding environment.

Unsuitable extinguishing media: Water spray jet

Special hazards arising from the substance or mixture

Hazardous combustion products: Carbon oxide

Advice for firefighters

Special protective equipment for firefighters: In the event of fire, wear self-contained breathing apparatus.
Firefighters must wear fire-resistant personal protective equipment.
Further information: In the event of fire, cool tanks with water spray. Avoid dust formation

Accidental release measures

Personal precautions, protective equipment and emergency procedures
Personal precautions: Evacuate personnel to safe areas. disposable one-piece overall with integral hood. Avoid breathing dust. Avoid dust formation.

Environmental precautions: Should not be released into the environment.

Methods and material for containment and cleaning up

Large spills: Sweep up or vacuum with HEPA filter or via wet cleaning into suitable containers for disposal.
Pick up and arrange without creating dust. Keep in properly labelled containers.

Small spills: Moisten a towel, cover the spill, pick up the spill or use HEPA vacuum.

Large spills + Small spills: Keep in suitable, closed containers for disposal. Treat recovered material as described in the section "Disposal considerations".

Handling and storage

Precautions for safe handling
Advice on safe handling: Ensure all equipment is electrically grounded before beginning transfer operations.
Avoid creating dust. To avoid thermal decomposition, do not overheat. Keep away from heat and sources of ignition.
Use personal protective equipment as required.

Advice on protection against fire and explosion: Take measures to prevent the build-up of electrostatic charge.
During processing, dust may form explosive mixture in air.

Hygiene measures: Handle in accordance with good industrial hygiene and safety practice.

Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers: To maintain product quality, do not store in heat or direct sunlight. Store in original container. Keep containers tightly closed in a cool, well-ventilated place. Store at room temperature.

Recommended storage temperature: 15 - 25 °C

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S

Chemical name:

(1,3-Benzenediamine, N1-[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]-6-methoxy-4-(4-morpholinyl)-)

Class or division:

Class 6: Toxic and infectious substances; Division 6.1

Packing group:

Packing group III: Substances presenting low danger

Labels:

6.1

Special provisions / remarks

Special provisions:

Packing group : III
Classification Code : T2
Hazard Identification Number : 60
Labels : 6.1
Tunnel restriction code : (E)

Remarks:

This substance can be shipped under 'de minimi's quantities' provisions if the net quantity per inner package <= 1mL for liquids or <= 1g for solids and the net quantity per outer package does not exceed 100mL for liquids or 100g for solids and provided packaging provisions of ADR/RID/ADN/IMDG §3.5.1.4 are met.

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S.

Chemical name:

(1,3-Benzenediamine, N1-[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]-6-methoxy-4-(4-morpholinyl)-)

Class or division:

Class 6: Toxic and infectious substances; Division 6.1

Packing group:

Packing group III: Substances presenting low danger

Labels:

6.1

Special provisions / remarks

Special provisions:

Packing group : III
Classification Code : T2
Hazard Identification Number : 60
Labels : 6.1

Remarks:

This substance can be shipped under 'de minimi's quantities' provisions if the net quantity per inner package <= 1mL for liquids or <= 1g for solids and the net quantity per outer package does not exceed 100mL for liquids or 100g for solids and provided packaging provisions of ADR/RID/ADN/IMDG §3.5.1.4 are met.

Marine transport (UN RTDG/IMDG)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S.

Chemical name:

(1,3-Benzenediamine, N1-[4-[4-[(dimethylamino)methyl]-3-
phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]-6-methoxy-4-(4-
morpholinyl)-)

Class or division:

Class 6: Toxic and infectious substances; Division 6.1

Packing group:

Packing group III: Substances presenting low danger

EmS code:

F-A

S-A

Labels:

6.1

Special provisions / remarks

Special provisions:

Packing group : III
Labels : 6.1
EmS Code : F-A, S-A

Remarks:

This substance can be shipped under 'de minimi's quantities' provisions if the net quantity per inner package <= 1mL for liquids or <= 1g for solids and the net quantity per outer package does not exceed 100mL for liquids or 100g for solids and provided packaging provisions of ADR/RID/ADN/IMDG §3.5.1.4 are met.

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

Toxic solid, organic, n.o.s.

Chemical name:

(1,3-Benzenediamine, N1-[4-[4-[(dimethylamino)methyl]-3-
phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]-6-methoxy-4-(4-
morpholinyl)-)

Class or division:

Class 6: Toxic and infectious substances; Division 6.1

Packing group:

Packing group III: Substances presenting low danger

Labels:

6.1

Special provisions / remarks

Special provisions:

Packing instruction (cargo aircraft): 677
Packing instruction (passenger aircraft): 670
Packing instruction (LQ) : Y645
Packing instruction (EQ) : E1
Packing group : III
Labels : 6.

Remarks:

This substance can be shipped under 'de minimi's quantities' provisions if the net quantity per inner package <= 1mL for liquids or <= 1g for solids and the net quantity per outer package does not exceed 100mL for liquids or 100g for solids and provided packaging provisions of IATA DGR §2.6.10 are met.

SpecialProvisions

Exposure controls / personal protection

Control parameters

Occupational Exposure Limits

Components	CAS-No	Value type (Form of exposure)	Control parameters	Basis
1,3-Benzenediamine, N1-[4-[4- [(dimethylamino)m ethyl]-3-phenyl-1Hpyrazol-1-yl]-2- pyrimidinyl]-6- methoxy-4-(4- morpholinyl)-	1903009-56-2	PBOEL_HHC	3A*	J&J OEL/PBOEL
Further information	J&J has a hazard banding notation: PBOEL HHC. This substance has no J&J PBOEL HHC classification as there is insufficient information. However the OEL is estimated to be from 5-20 µg/m3.

Exposure controls
Engineering measures: Engineering controls should be used as the primary means to control possible exposures. Use process enclosures, local exhaust ventilation or other engineering controls to keep exposure levels below recommended exposure limits.

Personal protective equipment

Eye protection: Safety glasses with side-shields

Hand protection Material : Nitrile rubber

Remarks: Impervious gloves Take note of the information given by the producer concerning permeability and breakthrough times,
and of special workplace conditions (mechanical strain, duration of contact).

Skin and body protection: closed work clothing disposable one-piece overall

Respiratory protection: Engineering controls should always be the primary method of controlling exposures. If respiratory protective equipment is needed for certain activities, the type, as well as the corresponding protection factor, will depend upon the risk assessment and air
concentrations, hazards, physical and warning properties of substances present.Use only respiratory protection that conforms to international/
national standards. Suitable mask with particle filter P3

Protective measures: The type of protective equipment must be selected according to the concentration and amount of the dangerous substance
at the specific workplace.

Stability and reactivity

Reactivity: None reasonably foreseeable

Chemical stability: Stable under recommended storage conditions.

Hazardous reactions: No data available

Conditions to avoid: Protect from frost, heat and sunlight.

Materials to avoid : Oxidizing agents

Hazardous decomposition products: Carbon oxides

Disposal considerations

Waste treatment methods

Product: In accordance with National, Federal, State and Local regulations.
Must be incinerated in a suitable incineration plant holding a permit delivered by the competent authorities.

Contaminated packaging: Empty containers should be taken to an approved waste handling site for recycling or disposal.