Allyl (2R,3S)-2-(3-bromo-2-oxopropyl)-3-methoxy-1-piperidinecarboxylate

Guidance on Safe Use

First-aid measures

Eye contact: Wash with plenty of water or saline. Keep the eyelids open during washing. Consult your doctor and show him the label.

Contact with the skin: Remove contaminated clothes (possibly shoes). Wash the affected part of the body with soap or mild detergent and rinse with plenty of water until the substance is completely removed (15-20 minutes). Notify the doctor immediately and show him the label.

Ingestion: In case of ingestion, rinse the mouth thoroughly with water. Notify your doctor immediately and show him the container or label.

Inhalation: Avoid breathing dust that could be generated by handling the product. Move the person to the open air in a well-ventilated area. Tell your doctor if the exposure was significant in terms of quantity or time.

Fire-fighting measures

Extinguishing media: Water spray, foam, dry chemical, carbon dioxide.

Hazardous combustion products: In the event of a fire, the substance can decompose with the emission of fumes harmful to health, such as COx and NOx.

Technical protection recommendations: Do not attempt to extinguish the fire without using an autonomous respiratory device (SCBA) and suitable protective clothing.

Special Protection Devices for firefighters: Wear boots, gloves, overalls, eye and face protection, suitable respirators.

Comply with the relevant UNI standards for Italy and EN for Europe. Use the devices indicated in the maximum precautionary conditions on the basis of the information reported in the previous sub-sections.

Accidental release measures

Eyes: Wear suitable protective equipment.

Skin: Wear clothing with full body protection.

Airways: In the event of fire and / or explosion, avoid breathing fumes and vapors. Use self-contained breathing apparatus (SCBA) and suitable protective clothing. The vapors can be removed by spraying with water.

In case of accidental release or spillage, prevent the substance from reaching the drains and can reach surface or ground water. Notify Competent Authorities in case of environmental pollution

Containment mode: Collect all the material scattered on the ground with adequate protective equipment and place it in a clean and dry container.

Method of remediation: Recover the substance by aspiration or other mechanical means and wash the area with plenty of water and detergents. Store the recovered product waiting for the specialized disposal company. If the payment is made on the highway or public place, appropriate measures must be adopted in order to protect people from any risk.

Handling and storage

Recommendations for handling:

Handle away from flames and sparks. Handle in a ventilated room. Avoid contact with incompatible materials / substances. Wear appropriate PPE. Keep the substance away from water discharges.

Professional hygiene recommendations:

Do not eat, drink or smoke in work areas. Wash hands after use. Remove contaminated clothing and PPE before accessing the areas where you eat.

The substance is not classified for any physical chemical properties and no special risk management mode is foreseen.

Risk management methods related to:

- potential ignition sources: Do not expose to heat sources.

How to contain the effects of:

- weather conditions: Do not expose to high temperatures, you could get the swelling of the container due to the development of gas.

- environmental pressure: No containment methods are envisaged.

- temperature: Store in the original tightly closed container in a cool and dry place.

- sunlight: Do not expose to direct sunlight.

- humidity: Do not store in a humid environment.

- vibrations: No containment methods are envisaged.

The application of the methods of managing the risks committed to the chemical-physical properties is to be carried out based on the risk assessments made by the employer in his working practice (use of the substance) in the absence of a unique and standardized exhibition scenario described in the Dossier registration REACH.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Community / national exposure limit values: OEB 3 (10 - 100 μg / m³)

Monitoring procedures:

The measurement of substances in the work environment must be carried out using standardized methods (eg UNI EN 689: 1997: Atmosphere in the workplace - Guidance on the evaluation of exposure by inhalation to chemical compounds for the purpose of comparison with limit values and measurement strategy; UNI EN 482: 2006: Atmospheres in the workplace - General requirements for the performance of procedures for the measurement of chemical agents) or, in their absence, with appropriate methods. Consider any occupational exposure values adopted during use.

The choice of the appropriate type of technical checks is based on the risk assessments made by the employer in his / her working practice (use of the substance) in the absence of a single and standardized exhibition scenario described in the REACH Registration Dossier.

The choice of the type of Individual Protection Device (s) is to be made based on the risk assessments made by the employer in his / her working practice (use of the substance) in the absence of a unique and standardized exhibition scenario described in the Dossier of REACH registration.

If, the results of the risk assessment, carried out in accordance with Directive 98/24 / EEC (In Italy the Legislative Decree 81 of 9 April 2008 and subsequent amendments) show that general and collective prevention measures are not sufficient to reduce the risk, and if it is not possible to prevent exposure to the substance by other means, adequate personal protective equipment must be adopted, in compliance with the relevant UNI / EN technical standards.

a) Eye / face protection: Safety glasses according to EN 166; facial screen

b) Skin protections:

- Hand protection:

Chemical resistant gloves according to EN 374, parts 1, 2 and 3 and EU directive 89/89 / EEC. The glove material must be waterproof and stable against the product / substance / formulation. Material: nitrile (nitrile rubber), hypoallergenic Thickness: not less than 0.12 mm

- Other, body protection

Choose the appropriate protective medium according to activity and exposure, e.g. apron, boots, suitable clothing according to EN 13982 in case of dust.

c) Respiratory protection:

If the risk assessment foresees the need for ventilators with assisted ventilation, use a dust filter type P1, P2 and P3 (EN 143). Use respirators and components tested and approved by the relevant standards bodies, such as NIOSH (USA) and CEN (EU). In the short and minimum exposures use the mask; wear the self-contained breathing apparatus in the most intense and lasting exposures

d) Thermal hazards:

Not provided for in standard use practices of the substance. Evaluate any personal protective equipment based on particular conditions of use of the same.

Stability and reactivity

The substance is not considered reactive under normal conditions of use.

The substance is stable under normal temperature and pressure conditions and if stored in closed containers in a cool, ventilated place.

Avoid exposure to light, air, moisture and excessive heat.

Incompatible materials: Oxidizing agents.

Hazardous decomposition products: For heating at high temperatures it decomposes, releasing fumes and toxic gases of COx and NOx.

Disposal considerations

Disposal through wastewater is not recommended.

Refer to the community / national / local provisions on waste disposal.

Respect the current legislation on waste disposal and recovery (Legislative Decree 152/06 and subsequent amendments).