Registration Dossier
Registration Dossier
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EC number: 700-455-1 | CAS number: 380843-75-4
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Study period:
- 16 June 2009 - 29 September 2009
- Reliability:
- 1 (reliable without restriction)
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- EC Number:
- 700-455-1
- Cas Number:
- 380843-75-4
- Molecular formula:
- C26H29Cl2N5O3
- IUPAC Name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- Details on test material:
- Equipment:
Differential Scanning Calorimeter: TA Instruments 2920 MDSC
Pressure DSC Cell: TA Instruments 916001.901
Closed-end Hg manometer: SGA Co. 21205
Sample pans: TA Instruments 900793.901
Hermetic lids with pinhole (75um dia.): TA Instruments 900860.901
Analytical Balance: Mettler-Toledo AT 261
Melting point Standards
Indium: Source: LGC2601; Certified Melting Temp.: 156.61ºC
Lead: Source: LGC2608; Certified Melting Temp.: 327.47ºC
Gallium: Source: NIST SRM2234; Certified Melting Temp.: 29.76ºC
Tin: Source: LGC2609 Certified Melting Temp.: 231.92ºC
Constituent 1
Results and discussion
Boiling pointopen allclose all
- Atm. press.:
- ca. 760 mm Hg
- Decomposition:
- yes
- Decomp. temp.:
- ca. 200 °C
- Remarks on result:
- other: The substance decomposes at normal ambient pressure, so a boiling point test was also performed under reduced pressure.
- Atm. press.:
- ca. 100 mm Hg
- Decomposition:
- yes
- Decomp. temp.:
- ca. 200
Applicant's summary and conclusion
- Conclusions:
- According to Annex VII, the boiling point does not need to be determined for substances which decompose before boiling.
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