Rifamycin, 3-formyl-

Guidance on Safe Use

First-aid measures

Description of first aid measures:

General information : Remove contaminated clothing immediately and store it in a safe place

If inhaled : In case of inhalation bring the injured person in the open air and consult a doctor.

In case of skin contact : Wash immediately and for a long time with plenty of water.

In case of eye contact : In case of contact with eyes, rinse immediately with plenty of water for 15 minutes. Consult a doctor immediately.

If swallowed : Let the injured person vomit autonomously only if he/she is fully conscious.Consult a doctor immediately

Most important symptoms and effects, both acute and delayed

Symptoms : No information available.

Dangers : No information available.

Indication of any need to immediately consult a doctor and special treatments

Treatment : Treatment of symptoms

Fire-fighting measures

Extinguishing media:

Suitable extinguishing media : Water, Carbon dioxide, dry extinguishing agent

Special hazards arising from the substance or mixture:

In the event of a fire, hazardous combustible gases are released:

Nitrogen oxides (NOx)

Carbon monoxide (CO)

Carbon dioxide (CO2)

Recommendations for fire fighters:

Special protective equipment for fire fighters: Use a self-contained breathing apparatus, Wear a complete protective suit

Further information : Use extinguishing systems compatible with the local situation and the surrounding environment. In compliance with current legislation, dispose of both contaminated extinguishing water and fire debris

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

personnel not belonging to the emergency team:

Move away immediately from the event location.

Use personal protective clothing. (see section: Exposure controls: Personal protection - Industrial scale)

personnel belonging to the emergency team:

Remove people from the place of accidental release

Isolate the area and prohibit entry to personnel not belonging to the emergency team.

Ventilate confined spaces before entering.

Use personal protective clothing. (see section: Exposure controls: Personal protection - Industrial scale)

Environmental precautions:

Do not let it enter into drains.

Do not disperse the spilled product in the soil or in surface water.

Methods and materials for containment and cleaning up:

General information : Spray spilled water to prevent dust formation.

Collect the substance with a stainless steel pallet and pour it into sealed PVC drums.

Send containers to waste.

Thoroughly clean contaminated objects and floors, in compliance with current legislation.

Collect the water used for washing with absorbent cloths for cleaning and send to the waste

Cleaning the contaminated area : Wash the contaminated area with plenty of water.

See also:Disposal considerations.

Further recommendations:

In case of emergency evacuate the area and request the intervention of emergency team.

Handling and storage

Precautions for safe handling:

Indications for safe use (industrial scale):

Work in a defined area with access restricted to only personnel. Avoid developing and depositing powders.

A closed transfer system is strongly recommended.

Avoid the accumulation of electrostatic charges.

Necessary equipotential connection of the plants and equipment. In the use of chemical products, observe the normal rules of prevention of work.

Indications for safe use (laboratory scale):

Handle in a chemical hood with filter.

Indications against fire and explosion:

Avoid the accumulation of electrostatic charges. Before starting up, inertize (with nitrogen or noble gases) and electrically connect equipment and devices to the ground.

Avoid the formation of dust.

Follow the general rules for fire prevention.

Conditions for safe storage, including any incompatibilities:

Requirements for storage and containers:

Store only in PVC drums with label.

Additional information for storage conditions:

Keep containers in a dry, cool and well-ventilated place.

Protect from sunlight.

Protect from air humidity and water.

Keep containers tightly closed.

Store only in PVC drums, at a temperature not exceeding 30 °C.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN3077

Shipping

Labels:

9/MP

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

Chemical name:

(3-Formyl-Rifamycin)

Labels:

9/MP

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

Chemical name:

(3-Formyl-Rifamycin)

Labels:

9/MP

Remarks

SpecialProvisions

Exposure controls / personal protection

Exposure controls:

Personal protection

General protection measures :

Intermediate to be used under strictly controlled conditions.

Do not breath the dust.

Personal protective equipment or collective protection devices must be chosen according to the workplace, concentration and amount of hazardous material handled.

Use ventilation and vacuum systems in production areas and laboratory analysis.

Clarify the chemical resistance of the protective means with the supplier.

Verify exposure to the substance by performing environmental and personal sampling.

Factory

Respiratory protection : (drums packaging) half-face mask EN 136 approved with P3 respiratory filter (transfer in reactor) full face mask approved EN 136 class 3 + P3 R D respiratory filter

Hand protection : The protective gloves to be used must comply with the specifications of the EC directive 89/686/E and the EN374 standard.

Material of which the gloves are made: Nitrile gloves

Layer thickness: 0.11 mm

Permeation time: > 480 min

EN388 (4-0-0-1)

EN374 JKl

EN1149

Eye protection :

Protective eyewear in accordance with EN 166

Lens marking:

2C-1.2 – xxxx - 1 FT CE

Frame marking:

xxxx - EN 166-FT CE

General marking of lenses + frame:

2C-1.2-xxxx-1 FT EN 166-FT CE

(where xxxx indicates the manufacturer)

Skin protection :

Protective clothing Cat. III

Protection against liquid chemicals

EN14605:2005 – (TYPE 4)

EN13982-1:2004/A1 2010 – (TYPE 5)

EN13034:2009 – (TYPE 6)

EN1149-52008 (antistatic)

Foot protection - safety footwear: EN ISO 20345 (S3)

Other indications for the construction of technical systems: The technical systems must be designed to ensure compliance with conditions subject to strict control.

Hygiene measures : Do not eat, drink or smoke during work.

Take a shower after work (recommended).

Laboratory

Respiratory protection : handle the product under a chemical hood

Hand protection :

Nitrile rubber gloves

Layer thickness: > 0.11 mm.

Penetration time: > 480 min

EN374

EN1149

Eye protection :

Protective eyewear in accordance with EN 166

Lens marking: 2C-1.2 – xxxx - 1 FT CE

Frame marking: xxxx - EN 166-FT CE

General marking of lenses + frame: 2C-1.2-xxxx-1 FT EN 166-FT CE

(where xxxx indicates the manufacturer)

Skin protection :

Clothing: work coat to knee height

EN13034:2009 – (TYPE 6)

Foot protection - safety footwear: EN ISO 20345 (S3)

Hygiene measures : Wash hands before breaks and at the end of the working day.

Do not eat, drink or smoke in work areas;

Remove contaminated clothing and protective equipment before accessing

the areas where you eat.

Stability and reactivity

References to engineering safety measures: Product powders could be explosive (no data available).

Avoid the accumulation of electrostatic charges.

Reactivity : No decomposition if used according to the appropriate instructions.

Chemical stability : No degradation occurs if stored under normal conditions.

Dangerous reactions : No dangerous reactions are known.

Conditions to avoid : No data available

Incompatible materials : Not known.

Hazardous decomposition products: Assuming a thermal decomposition: carbon monoxide and carbon dioxide nitrogen oxides

Disposal considerations

Waste treatment methods:

Product : In compliance with current legislation, send to an authorized landfill. Waste disposal - Code CER 160305*: organic waste, containing dangerous substances.

Uncleaned packaging : Packaging that cannot be cleaned should be disposed off as product waste.

CER 150110*: solid waste containing dangerous substances.

Materials come in contact with the substance (eg pvc packaging bags not usable): waste. CER 070513*: solid waste containing dangerous substances.