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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6/81 - 12/82
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No analysis of possible metabolites was performed.
Objective of study:
absorption
distribution
excretion
metabolism
Qualifier:
no guideline followed
GLP compliance:
no
Radiolabelling:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
single exposure: absorption, distribution, excretion, passage of placental barrier
five time exposure: accumulation
seven time exposure: metabolism
Remarks:
Doses / Concentrations:
single and five time exposure: 5 mg/kg body weight
seven time exposure: 50 mg/kg body weight
No. of animals per sex per dose / concentration:
absorption, distribution, excretion: 5 males and 5 females
metabolism: 3 males and 3 females
passage of placental barrier: 3 animals
Control animals:
no
Type:
absorption
Results:
blood concentration 0.001 % of administered dose after 240 min
Type:
excretion
Results:
93-96% after 24 hours
Key result
Test no.:
#1
Transfer type:
blood/placenta barrier
Key result
Test no.:
#1
Toxicokinetic parameters:
half-life 1st: 1-24 hours
Metabolites identified:
no
Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs.
3-Methylpyrazol crosses the placental barrier.
Executive summary:

After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs. 3-Methylpyrazol crosses the placental barrier.

Description of key information

Short description of key information on bioaccumulation potential result:

After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs. 3-Methylpyrazol crosses the placental barrier.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100

Additional information

One key study with Klimisch score 2 is available. The measured blood concentration of 3 -Methylpyrazole was 0.001 % of the administered dose after 240 minutes. Excretion reached 93 -96% after 24 hours.

Based on the high water solubility of 3 -Methylpyrazole the oral absorption rate was set to 100 %.