Grupa ekspertów ds. zaburzaczy hormonalnych
The Endocrine Disruptor Expert Group focuses on substances with endocrine disrupting properties. The most widely accepted definition for endocrine disruptors is the one by the International Programme for Chemical Safety (IPCS, 2002): "Endocrine disruptors have been defined as exogenous substances that alter function(s) of the endocrine system and consequently cause adverse health effects in an intact organism or its progeny, or (sub)populations". At present, the European Commission is developing criteria for the identification of such endocrine disrupting substances that require regulatory action.
Endocrine disruptors may be identified on a case-by-case basis as substances of very high concern (SVHCs), where there is scientific evidence of probable serious effects to human health or the environment, which give rise to an equivalent level of concern to CMR or PBT/vPvB substances (under Article 57(f) of REACH Regulation).
Endocrine disruptors interfere in some way with hormone action, and in doing so can produce adverse effects on human and wildlife health. The endocrine system is a complex network of glands, hormones and receptors. It provides the key communication and control link between the nervous system and bodily functions such as reproduction, immunity, metabolism and behaviour. The endocrine system controls growth and development during childhood, regulation of bodily functions in adulthood, and the reproductive process. The main evidence suggesting that exposure to chemicals can lead to the disruption of endocrine function comes from changes seen in a number of wildlife species. In humans, endocrine disruptors have been suggested as being responsible for apparent increases seen in human endocrine-related diseases and disorders over recent decades. Identifying chemicals with endocrine disrupting potential that require regulatory action among all the chemicals used remains a significant challenge.
The Endocrine Disruptor (ED) Expert Group provides informal, non-binding scientific advice on questions related to the identification of endocrine disrupting properties of chemicals. This advice does not anticipate or interfere with decision-making under the REACH Regulation, which exclusively remains the responsibility of the competent bodies designated in the REACH Regulation.
The ED Expert Group was established in February 2014 with the support of the Competent Authorities for REACH and CLP (CARACAL) and the Competent Authorities for Biocides. The expert group is coordinated and hosted by ECHA. Advice of the ED Expert Group on issues in relation to ED assessment may be requested by the participants of the ED Expert Group, EU Member State competent authorities under the REACH Regulation and the Biocides Regulation, and ECHA.
The expert group will provide informal and non-binding scientific advice on questions related to the identification of endocrine disrupting properties of chemicals and, in particular, on:
- Questions related to screening methods/activities to identify potential endocrine disruptors (e.g. for the CoRAP and/or Candidate List)
- Questions related to the development of integrated approaches to testing and assessment of endocrine disrupting properties
- Feedback and recommendations on complex (specific/generic) scientific issues related to information and (tiered) testing needs for potential endocrine disruptors (e.g. under dossier or substance evaluation or under the evaluation by the evaluating competent authority of a biocides active substance application)
- Specific questions on the interpretation of test data as well as other relevant information in relation to the identification of endocrine disrupting properties (e.g. during the development of an SVHC dossier or a biocides active substance evaluation).
Nominated experts from the following organisations are currently participating in the ED Expert Group:
- EU Member State Competent Authorities and EEA country representatives
- European Commission (DG Environment (ENV), DG Internal Market, Industry, Entrepreneurship and SMEs (GROW), DG Health and Food Safety (SANTE))
- The European Food Safety Authority (EFSA)
- Stakeholder organisations:
- Health and Environment Alliance (HEAL)
- Humane Society International
- European Environmental Bureau (EEB)
- European Trade Union Confederation (ETUC)
- European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC)
- The European Chemicals Industry Council (CEFIC)
- Organisation for Economic Co-operation and Development (OECD)
- Federal Office of Public Health, Switzerland (FOPH)
- Federal Office for the Environment, Switzerland (FOEN)
Experts nominated by the EU Member State competent authorities, the European Commission, other agencies of the European Union and ECHA's Accredited Stakeholder Organisations can participate in the meetings. For further information on the nomination procedure, please contact: ed_eg (at) echa.europa.eu.
In its meetings, the ED Expert Group discusses specific substance cases that are mainly suggested to the agenda by the participants from the EU Member State competent authorities carrying out ED assessments and needing advice. By March 2015 the group has discussed altogether 16 substances, 15 of which are included in the Community Rolling Action Plan (CoRAP). The outcomes of the assessments are published in the Public Activities Coordination Tool (PACT) when finalised.
The ED Expert Group also contributes to the development and improvement of mass screening approaches and criteria for searching the ECHA databases for potential ED substances. Further, the group is involved in assessing the screening results and selecting those substances for which a more in-depth assessment of their potential ED properties either under the CoRAP or on a voluntary basis is required.
The ED Expert Group meets three times per year:
|13th meeting||8-9 November 2018 (TBC)||N/A|
|12th meeting||9-10 October 2018 (TBC)||N/A|
|11th meeting||18-19 April 2018||Download|
|10th meeting||15-16 November 2017||Download|
|9th meeting||10-11 November 2016||Download|
|8th meeting||28-29 September 2016||N/A|
|7th meeting||21-22 April 2016 (cancelled)||N/A|
|6th meeting||21-22 October 2015||N/A|
|5th meeting||2-3 September 2015||N/A|
|4th meeting||24-25 February 2015||N/A|
|3rd meeting||11-12 November 2014||N/A|
|2nd meeting||22-23 May 2014||N/A|
|1st meeting||13-14 February 2014||N/A|