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EC number: 204-385-8 | CAS number: 120-32-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF values are more than an order of magnitude below the PBT criterion of BCF ≥ 2000. Chlorophene is not considered to have a significant bioaccumulation potential.
Key value for chemical safety assessment
Additional information
One study was performed with the tets item Chlorophene (CAS 120-32-1) according to OECD guideline 305 regarding the bioconcentration in fish Weyers, A. (2009).
During the uptake phase of the test, groups of 37 and 47 individuals of Danio rerio were exposed to Chlorophene (Preventol BP) at nominal concentrations of 3 µg/L and 15 µg/L for 15 days (8 days uptake phase, 7 days depuration phase).
Samples of the test media and of fish were taken on Day 1, 4, 6. 8, 9, 11 and 13 and analysed.
Mean recovery for the test item concentrations in water during the 8 d uptake phase according to analytical HPLC determinations was 100.2%. In fish samples 0.329% - 0.395% of Chlorophene (Preventol BP) could be determined via HPLC with a LOQ of analytical measurements of 0.09 µg/g fish fresh-weight for the test item concentration 3 µg/L and 1.433% - 2.046% for the test item concentration 15 µg/L, respectively. The mean fat content of fish was 6.8% at the beginning of the test. At the end of the test the mean fat content measured in the control was 8.5% and 12.7% for the test item concentration 15 µg/L.
After an exposure period of 8 d the uptake phase ended and fish were transferred into fresh medium free from Chlorophene (Preventol BP) and the depuration phase started. 24 hours later no test item could be determined in the fish samples any more. The steady state BCF was 107 L/kg for the test item concentration 3 μg/L and 110 L/kg for the test item concentration 15 μg/L. Because of the fast uptake and elimination kinetics, no rate constants and no kinetic BCF could be determined. The reported BCF values are more than an order of magnitude below the PBT criterion of BCF ≥ 2000. Chlorophene is not considered to have a significant bioaccumulation potential. The test is considered to be valid as all validity criteria were met (mortality in the control ≤ 10%, dissolved oxygen concentration > 60%, temperature of 20 – 25 °C and did not vary by more than ± 2 °C, test concentrations between 80 and 120% of nominal).
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