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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
no
Type of study:
Buehler test
Justification for non-LLNA method:
this study report was performed in 2003

Test material

Constituent 1
Chemical structure
Reference substance name:
Bornan-2-one
EC Number:
200-945-0
EC Name:
Bornan-2-one
Cas Number:
76-22-2
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid: crystalline

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, semiocclusive
Vehicle:
vegetable oil
Concentration / amount:
1g/mL
Challengeopen allclose all
Route:
epicutaneous, semiocclusive
Vehicle:
vegetable oil
Concentration / amount:
1g/mL
No. of animals per dose:
15

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
0.2ml
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0.2ml. No with. + reactions: 0.0. Total no. in groups: 15.0.
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
0.2mL
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.2mL. No with. + reactions: 0.0. Total no. in groups: 15.0.
Reading:
1st reading
Hours after challenge:
24
Group:
positive control
Dose level:
1% DNCB 0.2mL
No. with + reactions:
13
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: positive control. Dose level: 1% DNCB 0.2mL. No with. + reactions: 13.0. Total no. in groups: 15.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information