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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Mineral spirits inhalation associated with hemolysis, pulmonary edema and ventricular fibrillation.
Author:
Niehrenberg DW, Horowitz MB, Harris KM, & James DH
Year:
1991
Bibliographic source:
Arch Intern Med, 151: 1437-1440.

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
basic toxicokinetics
respiratory irritation
repeated dose toxicity: inhalation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
There was reported a near-fatal case of poisoning involving a 42-year-old woman who after several hours of painting in a closed room developed chest pain, cyanosis, apnoea and cardiac arrest with ventricular fibrillation.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Stoddard solvent
EC Number:
232-489-3
EC Name:
Stoddard solvent
Cas Number:
8052-41-3
Molecular formula:
C10H22
IUPAC Name:
stoddard solvent
Test material form:
liquid

Method

Type of population:
occupational
Subjects:
42-year-old woman who after several hours of painting in a closed room developed chest pain, cyanosis, apnoea and cardiac arrest with ventricular fibrillation.
Ethical approval:
no
Route of exposure:
inhalation
Reason of exposure:
intentional, occupational
Exposure assessment:
estimated
Details on exposure:
42-year-old woman who after several hours of painting in a closed room developed chest pain, cyanosis, apnoea and cardiac arrest with ventricular fibrillation.
Examinations:
pulmonary oedema, haemolytic anaemia and metabolic abnormalities were observed.

Results and discussion

Results of examinations:
During hospitalization, pulmonary oedema, haemolytic anaemia and metabolic abnormalities were observed

Applicant's summary and conclusion

Conclusions:
There was reported a near-fatal case of poisoning involving a 42-year-old woman who after several hours of painting in a closed room developed chest pain, cyanosis, apnoea and cardiac arrest with ventricular fibrillation. During hospitalization, pulmonary oedema, haemolytic anaemia and metabolic abnormalities were observed. The exposure from the white spirit in the lacquer and paint she was using was estimated to be very high because of the lack of ventilation.