Stoddard solvent

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Effects on the nervous system

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Prospective clinical and psychometric investigation of patients with chronic toxic encephalopathy induced by solvents.

Author:

Oerbaek P & Lindgren M

Year:

1988

Bibliographic source:

Scand J Work Health, 14: 37-44.

Reference 2

Reference Type:

publication

Title:

Patients suffering from organic solvent psycho syndrome.

Author:

Oerbaek P, Lindgren M, & Haeger-Aronsen B

Year:

1986

Bibliographic source:

Läkartidningen, 83(32/33): 2647-2651

Materials and methods

Study type:

medical screening

Endpoint addressed:

neurotoxicity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

There was conducted a follow-up study with 32 workers (25 painters) previously diagnosed with solvent-induced chronic toxic encephalopathy. After 21-88 months without exposure, the workers were retested with the neuropsychological tests conducted at the time of the diagnosis.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Stoddard solvent

EC Number:

232-489-3

EC Name:

Stoddard solvent

Cas Number:

8052-41-3

Molecular formula:

C10H22

IUPAC Name:

stoddard solvent

Test material form:

liquid

Method

Type of population:

occupational

Ethical approval:

confirmed, but no further information available

Details on study design:

There was conducted a follow-up study with 32 workers (25 painters) previously diagnosed with solvent-induced chronic toxic encephalopathy. After 21-88 months without exposure, the workers were retested with the neuropsychological tests conducted at the time of the diagnosis.

Results and discussion

Results:

Significant improvement was seen in a test for visual perception whereas impairment was found in tests for verbal memory and simple reaction time. Improvement was reported in subjective symptoms, especially with respect to irritability, headache and dizziness, whereas impairment was noted with respect to short-term memory, peripheral sensory perception and anxiety. In conclusion, impaired intellectual function was judged to be permanently affected, since no firm conclusion could be drawn with respect to overall improvement/ impairment in the exposure-free period.

Applicant's summary and conclusion

Conclusions:

Significant improvement was seen in a test for visual perception whereas impairment was found in tests for verbal memory and simple reaction time. Improvement was reported in subjective symptoms, especially with respect to irritability, headache and dizziness, whereas impairment was noted with respect to short-term memory, peripheral sensory perception and anxiety. In conclusion, impaired intellectual function was judged to be permanently affected, since no firm conclusion could be drawn with respect to overall improvement/ impairment in the exposure-free period.