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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
The substance is readily biodegradable and considered to be of low risk to fish. - Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : CCCCCCCCCC
CHEM : Stoddard solvent
CAS Num: 8052-41-3
MOL FOR: C10 H22
MOL WT : 142.29
Log Kow: 5.252 (EPISuite Kowwin v1.68 Estimate)
Log Kow: 5.01 (PhysProp DB exp value - for comparison only)
Melt Pt: -29.70 (deg C, PhysProp DB exp value for Wat Sol est)
Wat Sol: 1.409 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: 0.052 (mg/L, PhysProp DB exp value) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.02 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: toxic , as determined by (Q)SAR
- Details on results:
- A NOEC value of 0.02 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is expected to be toxic .
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A NOEC value of 0.02 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is expected to be toxic .
The model indicated that Stoddard solvent possess properties indicating a potential hazard for the environment based on nominal loadings. - Executive summary:
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 0.02 mg/l . This result signifies that the test substance is expected to be toxic .
The model indicated that Stoddard solvent possess properties indicating a potential hazard for the environment based on nominal loadings.
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : CCCCCCCCCC
CHEM : Stoddard solvent
CAS Num: 8052-41-3
MOL FOR: C10 H22
MOL WT : 142.29
Log Kow: 5.252 (EPISuite Kowwin v1.68 Estimate)
Log Kow: 5.01 (PhysProp DB exp value - for comparison only)
Melt Pt: -29.70 (deg C, PhysProp DB exp value for Wat Sol est)
Wat Sol: 1.409 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: 0.052 (mg/L, PhysProp DB exp value) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.142 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic at the limit of solubility, as determined by (Q)SAR
- Details on results:
- A NOEC value of 0.142 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A NOEC value of 0.142 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.
The model indicated that Stoddard solvent possess properties indicating a potential hazard for the environment (acute toxicity for fish, invertebrates, and algae (in the range of 0.1 – 1.0 mg/l) based on nominal loadings. - Executive summary:
The ECOSAR QSAR model predicts that the NOEC for marinewater fish would to be 0.142 mg/l .This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.
The model indicated that Stoddard solvent possess properties indicating a potential hazard for the environment (acute toxicity for fish, invertebrates, and algae (in the range of 0.1 – 1.0 mg/l) based on nominal loadings.
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- other: Published data
- Adequacy of study:
- weight of evidence
- Study period:
- 112 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Published data in readily available literature. A 112 days chronic study was conducted with CAS RN 8008-20-6, using rainbow trout, Oncorhynchus mykiss.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Principles of method if other than guideline:
- A chronic bioassay test procedure was run in a flow-through experiment, starting with rainbow trout eggs which were exposed to 4 concentrations of the water-soluble fraction (WSF) of jet fuel JP-8, corresponding to 1.4 to 8.0 mg/l of dissolved hydrocarbons.
Hatching was complete by day 4 and tests continued to day 112 using the same WSF dilutions. - GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Fish were exposed to the water soluble fraction (WSF) of JP-8 in static acute bioassays and continuous-flow bioassays of approx. 4 months duration.
- Vehicle:
- yes
- Details on test solutions:
- Test treatments were prepared as WAFs in sealed test vessels to contain the volatile components.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow trout (Oncorhynchus mykiss)
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 112 d
- Hardness:
- The water used in this study had a total hardness range of 170-180 mg/l as CaCO3
- Test temperature:
- Water temperature was 15 to 28° C
The toxicity of JP-8 to cold and warm water fish was investigated to help define the impact on fresh water species - pH:
- 7.3–9.1
- Dissolved oxygen:
- average: 6.0 mg/L (4.4 to 7.2 mg/L)
- Salinity:
- N.A.
- Nominal and measured concentrations:
- 4 concentrations of the water-soluble fraction (WSF) of jet fuel JP-8, corresponding to 1.4 to 8.0 mg/l of dissolved hydrocarbons.
- Reference substance (positive control):
- no
- Duration:
- 112 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 112 d
- Dose descriptor:
- LOEC
- Effect conc.:
- ca. 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- The NOEC for the study was < 1.4 mg/l, and was based on the growth rate of young fish.
The LOEC was 1.4mg/l. - Validity criteria fulfilled:
- yes
- Conclusions:
- 112 day NOEC values < 1. 4 mg/L were determined for the effects of the test substance on growth of the larvae of freshwater fish Rainbow trout (O. mykiss) .
The LOECwas 1.4mg/l - Executive summary:
The NOEC for the study was < 1.4 mg/l, and was based on the growth rate of young fish.
The LOEC was 1.4mg/l.
Referenceopen allclose all
Overview of QSARs estimations onlong-term aquatic toxicity of Stoddard solvent to fish
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Fish, 96-hr LC50 =0.140 mg/L (ppm) Fish 30-day ChV = 0.020 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Fish, 96-hr LC50 =0.140mg/L (ppm)
Fish 30-day ChV =0.020mg/L (ppm)
Overview of QSARs estimations onlong-term aquatic toxicity of Stoddard solvent to fish
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Fish, 96-hr LC50 =0.140 mg/L (ppm) Fish, 96-hr (SW) LC50 =0.180 mg/L (ppm) Fish 30-day ChV = 0.020 mg/L (ppm) Fish (SW) 30-day ChV = 0.142 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Fish, 96-hr LC50 =0.140mg/L (ppm)
Fish, 96-hr (SW) LC50 =0.180mg/L (ppm)
Fish 30-day ChV =0.020mg/L (ppm)
Fish (SW) 30-day ChV = 0.142mg/L (ppm)
Rainbow trout exposed to a dissolved hydrocarbon concentration of 1.4 mg/l grew at a rate significantly lower than the controls. Mortality of fish exposed to concentrations over 1.4 mg/l was significantly greater than that of the controls.
The extent of egg hatching was not affected at a concentration of 8.0 mg/l of dissolved hydrocarbons.
Description of key information
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 0.02 mg/l
The ECOSAR QSAR model predicts that the NOEC for marinewater fish would to be 0.142 mg/l
112 day NOEC values < 1. 4 mg/L were determined for the effects of the test substance on growth of the larvae of freshwater fish Rainbow trout (O. mykiss) .
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.4 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0.142 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
