2,6-di-tert-butyl-p-cresol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: acceptable, well-documented publication/study report which meets basic scientific principles

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Hazard assessment of butylated hydroxytoluene from urethane carpet cushions.

Author:

US Consumer Product Safety Commission

Year:

1998

Bibliographic source:

US Consumer Product Safety Commission, Bethesda, MD, USA

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1998

Reference 3

Reference Type:

other: abstract

Title:

Sensory irritation in mice with carpet emission chemicals

Author:

Stadler, J., C.; et al.

Year:

1997

Bibliographic source:

The Toxicologist, Fundamental and Applied Toxicology, Abstracts of the 36th Annual Meeting, vol. 36, no. 1, part 2, March 97, 1670

Reference 4

Reference Type:

other: abstract

Title:

Adaptation of athreshold model for use in evaluation additivity of sensory irritants

Author:

Stadler, J., C.; et al.

Year:

1998

Bibliographic source:

SOT 1998 Annual Meeting, 1230

Materials and methods

Principles of method if other than guideline:

other: sensory irritation study of BHT

GLP compliance:

yes

Test type:

other: sensory irritation study

Test material

Test material information

Constituent 1

Reference substance name:

2,6-di-tert-butyl-p-cresol

EC Number:

204-881-4

EC Name:

2,6-di-tert-butyl-p-cresol

Cas Number:

128-37-0

Molecular formula:

C15H24O

IUPAC Name:

2,6-di-tert-butyl-4-methylphenol

Details on test material:

BHT purity: >99.9%

Test animals

Species:

mouse

Strain:

Swiss Webster

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

head only

Vehicle:

other: unchanged (no vehicle)

Duration of exposure:

30 min

Concentrations:

4.54, 16.0, 32.1, 42.9, 66.6 and 82.6 ppm

No. of animals per sex per dose:

4

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

other: RD50

Effect level:

59.7 ppm

Based on:

test mat.

Exp. duration:

30 min

Remarks on result:

other: sensory irritation study

Any other information on results incl. tables

In this study for sensory irritation, 6 groups of 4 male Swiss Weber mice were exposed to BHT concentrations of 4.54, 16, 32, 42.9, 66.6 and 82.6 ml/m³ (head only exposure) for 30 minutes. The RD50 was calculated to be 59.7 ml/m³ (about 546 mg/m³). No indication of sensory irritations was observed at concentrations of 4.54 and 16 ml/m³ (about 41 and 146 mg/m³, respectively). The RD50 of 3.6 ml/m³ (Stadler and Lavoie 1997) reported in an earlier study by DuPont was thus not substantiated; the discrepancy was explained by problems in the analysis (recovery) in the DuPont study (US Consumer Product Safety Commission 1998).

Applicant's summary and conclusion

Executive summary:

In this study for sensory irritation, 6 groups of 4 male Swiss Weber mice were exposed to BHT concentrations of 4.54, 16, 32, 42.9, 66.6 and 82.6 ml/m³ (head only exposure) for 30 minutes. The RD50 was calculated to be 59.7 ml/m³ (about 546 mg/m³). No indication of sensory irritations was observed at concentrations of 4.54 and 16 ml/m³ (about 41 and 146 mg/m³, respectively) (US Consumer Product Safety Commission 1998).