Registration Dossier
Registration Dossier
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EC number: 212-828-1 | CAS number: 872-50-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 000 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 1 107 mg/L
Additional information
Considering the acute toxicity to aquatic
invertebrates, two key studies were identified, one for marine and one
for freshwater invertebrates:
- To determine the toxicity of 1-Methyl-2-pyrrolidone to freshwater
invertebrates, a static non-GLP study following German Industrial
Standard DIN 38412 part 11 using Daphnia magna was performed (BASF AG,
1982). Based on nominal test concentrations, a 24 -h EC50 of >1000 mg/L
was determined.
- As key study concerning acute toxicity to marine invertebrates a test
performed by the Aquatic Toxicology Laboratory, SRC, Syracuse on behalf
of GAF Corporation (1979) according to US EPA guideline 660/3 -75 -009
was identified. As test species the grass shrimp (Palaemonetes vulgaris)
has been applied. In this static test, an EC50 (96h) of 1107 mg/L
(nominal) was found.
According to REACH Guidance R.7b, section R.7.8.4.1 (ECHA, 2017) a test duration of 48 hours is standard for daphnids. 24 hour values should be considered only in the absence of good quality 48 hour values and in conjunction with other available data. For other crustacea, such as mysids or others, a duration of 96 hours is typical. Therefore, the available data (freshwater: 24-h EC50; marine: 96-h EC50) are sufficient in terms of chemical safety assessment.
Based on the available experimental data, 1-Methyl-2-pyrrolidone (CAS 872-50-4) is concluded to be with high probability acutely not harmful to aquatic invertebrates.
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