Registration Dossier
Registration Dossier
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EC number: 224-235-5 | CAS number: 4259-15-8
Endpoint summary
Administrative data
Description of key information
This substance is not a skin irritant, is an eye irritant at 100%, but not an eye irritant at a 50% concentration.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
No data on respiratory irritation are available for the test material.
No skin irritation was observed in an animal study in which the test substance was administered as supplied and held in place under semi-occlusive wrap for 4 hours.
At 100%, the test material had irritant effects on the mucous membranes of the eyes, not reversible within 21 days in three of six rabbits, but at 50% concentration, no ocular irritation was observed. The studies are found to be adequate to fulfill the purposes of this endpoint.
The following information is taken into account for any hazard / risk assessment:
This substance is not a skin irritant, is an eye irritant at 100%, but not an eye irritant at a 50% concentration.
Effects on eye irritation: irritating
Justification for classification or non-classification
There are conclusive but not sufficient data for classification of the test material with regard to skin irritation / corrosion, so the test material is not classified for this endpoint in accordance to Directive 67/548/EEC or the CLP Regulation (EC) No 1272/2008.
The test material is classified for eye irritation endpoints in accordance to Directive 67/548/EEC or the CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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