Registration Dossier
Registration Dossier
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EC number: 204-468-9 | CAS number: 121-43-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Boric acid was tested in a Buehler method skin sensitisation test (Wnorowski, 1994 ) applied at a concentration of 95 % (powder moistened with water) during both the induction and challenge phase of the test. No signs of skin sensitisation were observed.No evidence of skin sensitisation in humans exposed occupationally to borates has been reported (Bruze et al., 1995).
In two Magnussen Kligman guinea pig studies, methanol did not show any relevant skin sensitisation potential (BASF AG 1979a and b).
Based on the evidence on both hydrolysis products, boric acid and methanol, TMB is judged to have no relevant potential for skin sensitisation.
Migrated from Short description of key information:
Based on the evidence on both hydrolysis products, boric acid and methanol, TMB is judged to have no relevant potential for skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no data to suggest that boric acid is a respiratory sensitiser.
Migrated from Short description of key information:
There are no data to suggest that boric acid is a respiratory sensitiser.
Justification for classification or non-classification
No classification is required for trimethyl borate as the hydrolysis products boric acid and methnaol did not show any potential for skin or respiratory sensitisation.
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