Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

DIDP is a non-genotoxic agent.


Short description of key information:
DIDP is not mutagenic in vitro in bacterial mutation assays (with and without metabolic activation) and is negative in a mouse lymphoma assay (Zeiger et al., 1982; 1985; Hazleton Biotechnologies Company, 1986; Barber et al., 2000). DIDP is not clastogenic in a mouse micronucleus assay in vivo (Hazleton Washington, 1994; McKee et al., 2000).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Substances known to be mutagenic to man (Category 1) or substances which should be regarded as if they are mutagenic to man (Category 2) based on sufficient animal studies or other relevant information also defines the criterion for T. DIDP is not mutagenic in in vitro bacterial mutation assays (with and without metabolic activation) and is negative in a mouse lymphoma assay (Zeiger et al., 1982; 1985; Hazleton Biotechnologies Company, 1986; Barber et al., 2000). DIDP is not clastogenic in a mouse micronucleus assay in vivo (Hazelton Washington, 1994; McKee et al., 2000). Therefore, DIDP is a non-genotoxic agent which does not meet the criterion for T based on mutagenicity.