Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-816-9 | CAS number: 17865-07-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: Based on experimental results obtained in short-term toxicity to fish studies (reliability 2) with supporting substance acetic acid, read-across approach was applied and LC50 (96h) for propyltriacetoxysilane was calculated to be 108.89 mg/L (based on mortality).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 108.89 mg/L
Additional information
Weight of evidence:
Read-across from experimental results with acetic acid:
In the first study, Wallen et. al., 1957 (reliability 2), an acute toxicity testwas performed according to OECD Guideline 302. The LC50 (based on mortality) of test material, acetic acid, in Gambusia affinis for 96h exposure period was 251 mg/L. Based on this experimental result, read-across approach was applied and LC50 (96h, based on mortality) for propyltriacetoxysilane was calculated to be 345.97 mg/L.
In the study of Juhnke et. al, 1978 (reliability 2), an acute toxicity test was performed according to German Standard Method for Waste Water and Sludge of 1976 with test material acetic acid. The LC50 for 48h toxicity on the golden orfe (Leuscicus idul melanotus) was 410 mg/L (basis for effect: mortality). Based on this result, read-across approach was applied and LC50 (48h, based on mortality) for propyltriacetoxysilane was calculated to be 565.12 mg/L.
In the study of Mattson et. al., 1976 (reliability 2), Fathead minnow (Pimephales promelas) were exposed under static conditions to a series of concentrations of acetic acid. The 96 h LC50 was 79-88 mg/L (basis for effect: mortality). Based on this experimental result obtained with the supporting substance acetic acid, read-across approach was applied and the LC50 (96h) for propyltriacetoxysilane was calculated to be 108.89-121.29 mg/L (basis for effect: mortality).
Supporting studies:
Read-across from experimental results with sodium acetate:
There are two supporting studies from DeYoung et. al., 1996 and Terhaar et. al., 1972, both with reliability 2 performed for the supporting substance sodium acetate. In the first one and based on the experimental results (120h LC50 = 13330 mg/L for Pimephales promelas), read-across approach was applied and the 120h LC50 for propyltriacetoxysilane was calculated to be 13450 mg/L. In the second study and based on the experimental results (96h LC50 = 10000 mg/L for Pimephales promelas), the read-across approach was applied and the 96h LC50 for propyltriacetoxysilane was calculated to be 10090 mg/L.
According to the available information on short-term toxicity to fish, could be pointed out that the toxicity of propyltriacetoxysilane is caused by the pH effect of acetic acid since the read-across approach applied from experimental data with acetic acid (LC50 (96): 345.97 mg/L; LC50 (48h): 565.12; LC (96h): 108.89 -121.29 mg/L) is much more restrictive than the values obtained with the read-across approach from experimental data with sodium acetate, the neutralised form of the acid (LC50 (120h): 13450 mg/L); LC50 (96h): 10090 mg/L).
Key value for chemical safety assessment:
According to the read-across approaches from experimental results with supporting substance acetic acid, the propyltriacetoxysilane key value for chemical safety assessment is calculated to be LC50 = 108.89 mg/L (based on mortality). This value is the most restrictive and it was obtain by the reach-across approach from the reliable study by Mattson et.al., 1976.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.