Registration Dossier
Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (3 h): 0.6 mg a.i./L (nominal, OECD 209, total respiration, activated sludge microorganisms)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 0.6 mg/L
Additional information
The available key study (2014), in which the toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to activated sludge microorganisms of a predominantly domestic sewage treatment plant was investigated, was performed according to the OECD Guideline No. 209 (GLP). Activated sludge microorganisms were exposed for 3 h to nominal test item concentrations of 0, 0.1, 0.3, 1.0, 3.2, 10 mg/L in the presence and absence of the nitrification inhibitor N-allythiourea. Concentration dependent effects on the total respiration rate and respiration rate due to nitrification of the activated sludge microorganisms were observed after 3 h of exposure. The 3-hour EC10 and EC50 for total respiration were calculated to be 0.6 and 18.2 mg a.i./L (nominal), respectively. For heterotrophic respiration, no dose related effects could be determined while the 3-hour EC 10 and EC50 for oxygen uptake due to nitrification were calculated to be 2.1 and 6.9 mg a.s./L (nominal), respectively.
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