Registration Dossier
Registration Dossier
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EC number: 295-536-7 | CAS number: 92062-22-1 A complex combination of organic compounds obtained from brown coal gasification. Composed primarily of C6-10 hydroxy aromatic phenols and their homologs.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 405 with acceptable restrictions (partly limited documentation of methods, e.g. no details about the test substance; results presented in an abstract form).
Data source
Reference
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits
- Author:
- Flickinger CW
- Year:
- 1 976
- Bibliographic source:
- Am Ind Hyg Assoc J 37: 596-606
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- procedure according to FHSA published in the Federal Register of August 12, 1961, pages 7333-7341, entitled "Part 191 - Hazardous Substances: Definitions·and Procedural and Interpretative Regulatrons, Final Order"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
- Details on test material:
- Source: Fisher Scientific company, catalogue no. A-91
No further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino rabbits, no further data
- Details on test animals or tissues and environmental conditions:
- no details
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- no wash-out
- Observation period (in vivo):
- up to 14 days
- Number of animals or in vitro replicates:
- at least 2 (no details)
- Details on study design:
- No further details given.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 105
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks:
- within 14 days
- Remarks on result:
- other: keratoconus and pannus formation
- Irritant / corrosive response data:
- Upon the application of 100 mg of phenol into the eyes, the conjunctivae became inflamed, the corneas opaque, and the rabbits gave evidence of marked discomfort. Examination of the exposed eyes 24 hours following exposure showed severe conjunctivitis, iritis, corneal opacities occluding most of the iris, and corneal ulcerations extending over the entire corneal surface. There was almost no perceptible improvement in the condition of the eyes during the observation period, and by the 14th day all of the exposed eyes exhibited keratoconus and pannus formation.
- Other effects:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Phenol is corrosive to the eye.
- Executive summary:
The study is comparable to OECD Guideline 405 with acceptable restrictions (partly limited documentation of methods, e.g. no details about the test substance; results presented in an abstract form).
Rabbits received instillations of 100 mg phenol into the conjuntival sac. Effects were recorded up to 14 days after application. Upon the application the conjunctivae became inflamed, the corneas opaque, and the rabbits gave evidence of marked discomfort. Examination of the exposed eyes 24 hours following exposure showed severe conjunctivitis, iritis, corneal opacities occluding most of the iris, and corneal ulcerations extending over the entire corneal surface. There was almost no perceptible improvement in the condition of the eyes during the observation period, and by the 14th day all of the exposed eyes exhibited keratoconus and pannus formation.
Conclusion: Phenol is corrosive to the eye.
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