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Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Alternatives to vertebrate testing

As of 11 September 2015 ECHA is inviting registrants that make testing proposals involving vertebrate animals for details on how they have considered alternative methods to address the missing information. This is a follow-up action of the European Ombudsman's conclusion in case 1606/2013 on 11 September 2015. A link to the registrant's considerations on alternatives to testing is published below with the related testing proposal. indicated The field is empty when the testing proposal was submitted before 11 September 2015 or when the registrant has not submitted a report on his considerations on alternatives to testing

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

35 resultaten.
 
4-(1-oxo-2-propenyl)-morpholine 418-140-1 5117-12-4 05/11/2020 Genetic toxicity in vivo Give Comments
Benzenamine, reaction products with aniline hydrochloride and nitrobenzene, hydrochlorides 309-913-1 101357-16-8 05/11/2020 Sub-chronic toxicity (90-day): oral Give Comments
Di(tetraethylammonium)hexahydroxoplatinate(IV) 848-537-7 1912392-88-1 05/11/2020 Genetic toxicity in vivo Give Comments
Diethylamine 203-716-3 109-89-7 05/11/2020 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Dimethylamine (CAS 124-40-3) Give Comments
Cobalt 231-158-0 7440-48-4
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
Cobalt bis(2-ethylhexanoate) 205-250-6 136-52-7
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
cobalt di(acetate) 200-755-8 71-48-7
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant
Cobalt dichloride 231-589-4 7646-79-9
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: Testing proposal is based on concern identified by the registrant.
Cobalt lithium dioxide 235-362-0 12190-79-3
05/11/2020
05/11/2020
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant.
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Cobalt oxalate 212-409-3 814-89-1
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
Cobalt(II) 4-oxopent-2-en-2-olate 237-855-6 14024-48-7
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
"Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant. "
Cobalt, borate propionate complexes 295-033-2 91782-61-5
05/11/2020
05/11/2020
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
Cobalt hydroxide oxide 234-614-7 12016-80-7
05/11/2020
05/11/2020
05/11/2020
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Cobalt sulphide (EC 215-273-3) || Note: Testing proposal is based on concern identified by the registrant.
Cobalt sulphide 215-273-3 1317-42-6
05/11/2020
05/11/2020
05/11/2020
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
Tricobalt tetraoxide 215-157-2 1308-06-1
05/11/2020
05/11/2020
05/11/2020
Sub-chronic toxicity (90 day): inhalation
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Cobalt sulphide (EC 215-273-3) || Note: Testing proposal is based on concern identified by the registrant.
(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl triacrylate 254-843-6 40220-08-4 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
14H-benz[4,5]isoquino[2,1-a]perimidin-14-one 229-904-5 6829-22-7 03/12/2020 Genetic toxicity in vivo Give Comments
2,3-epoxypropyl isopropyl ether 223-672-9 4016-14-2 03/12/2020 Genetic toxicity in vivo Give Comments
3-(benzothiazol-2-yl)-7-(diethylamino)-2-oxo-2H-1-benzopyran-4-carbonitrile 274-668-9 70546-25-7 03/12/2020 Genetic toxicity in vivo Give Comments
4-[3-(1-naphthylamino)propyl]morpholine 226-033-2 5235-82-5 03/12/2020 Genetic toxicity in vivo Give Comments
5-bromo-5-nitro-1,3-dioxane 250-001-7 30007-47-7 03/12/2020 Genetic toxicity in vivo Give Comments
7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate 276-957-5 72869-86-4 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
[1R-(1α,2β,5α)]-1-(isopropyl)-2-methoxy-4-methylcyclohexane 216-365-6 1565-76-0 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Cyclohexanone, peroxide 235-527-7 12262-58-7 03/12/2020 Genetic toxicity in vivo Give Comments
Dirhodium trisulphate 234-014-5 10489-46-0 03/12/2020 Genetic toxicity in vivo Give Comments
Disodium 5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxy-6-(methylamino)naphthalene-2-sulphonate 274-436-7 70210-39-8 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Essential oil of Spearmint obtained from the aerial part of Mentha spicata and/or Mentha cardiaca (Lamiaceae) obtained by distillation 946-253-9 - 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Phosphoric acid, C11-14 (C13-rich)-isoalkyl mono- and di-esters, partially salted with 1-Propanamine, 3-(tridecyloxy)-, branched 947-480-6 - 03/12/2020 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant Give Comments
Reaction mass of Disodium dihydroxy[3-(hydroxy-kO)-4-{[5-(hydroxy-kO)-3-methyl-1-phenyl-1Hpyrazol-4-yl]diazenyl-kN1}naphthalene-1-sulfonato(3-)]chromate(2-) and sodium [4-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-3-hydroxynaphthalene-1-sulphonato(3-)]hydroxychromate(1-) 944-272-7 - 03/12/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Reaction mass of N-butylphthalimide and N-sec-butylphthalimide and N-propylphthalimide 943-947-3 - 03/12/2020 Genetic toxicity in vivo Give Comments
(E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene 807-113-1 3709-71-5
03/12/2020
03/12/2020
Sub-chronic toxicity (90 day): inhalation
Reproductive toxicity (pre-natal developmental toxicity)
1,2-dimethylimidazole 217-101-2 1739-84-0
03/12/2020
03/12/2020
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
1,5-Pentanediamine, 2-methyl-, reaction products with 2-ethyl-1,4-butanediamine and glycidyl tolyl ether 291-813-1 90480-76-5
03/12/2020
03/12/2020
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide 271-794-6 68608-66-2
03/12/2020
03/12/2020
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Alkylamidoamine glycinate majority C12, 14 (amphoacetate) EC 931-291-0 || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Alkylamidoamine glycinate majority C12, 14 (amphoacetate) EC 931-291-0. || Note: Testing proposal is based on concern identified by the registrant
Fatty acids, C12-18 (even numbered)-methyl esters, sulfonated, sodium salts 947-394-9 -
03/12/2020
03/12/2020
03/12/2020
Long-term toxicity to fish
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
35 resultaten.



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