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Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Alternatives to vertebrate testing

As of 11 September 2015 ECHA is inviting registrants that make testing proposals involving vertebrate animals for details on how they have considered alternative methods to address the missing information. This is a follow-up action of the European Ombudsman's conclusion in case 1606/2013 on 11 September 2015. A link to the registrant's considerations on alternatives to testing is published below with the related testing proposal. indicated The field is empty when the testing proposal was submitted before 11 September 2015 or when the registrant has not submitted a report on his considerations on alternatives to testing

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

29 resultaten.
 
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
07/05/2020
07/05/2020
Bioaccumulation test (Bioconcentration: Flow-through Fish Test)
Reproductive toxicity (pre-natal developmental toxicity)
1,4-phenylenebis[(4-phenoxyphenyl)methanone] 620-097-9 54299-17-1 09/04/2020 Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) Give Comments
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate 224-116-8 4203-89-8 07/05/2020 Genetic toxicity in vivo Give Comments
4-phenylbutenone 204-555-1 122-57-6 07/05/2020 Genetic toxicity in vivo Give Comments
Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide 810-703-1 1187441-10-6 07/05/2020 Genetic toxicity in vivo Give Comments
2-[[(butylamino)carbonyl]oxy]ethyl acrylate 264-036-0 63225-53-6 07/05/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Dimethyl (p-methoxybenzylidene)malonate 231-185-8 7443-25-6 07/05/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Dialkyl-methyl-dihydro-heteropolycyle 815-131-6 913171-06-9 07/05/2020 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. Give Comments
Dibutyl itaconate 218-451-9 2155-60-4
09/04/2020
09/04/2020
Genetic toxicity in vivo
Sub-chronic toxicity (90-day): oral
tert-butyl perbenzoate 210-382-2 614-45-9 07/05/2020 Long-term toxicity to fish Give Comments
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] 284-366-9 84852-53-9 09/04/2020 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid 931-291-0 -
07/05/2020
07/05/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Benzyldimethylamine 203-149-1 103-83-3
07/05/2020
07/05/2020
07/05/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8 07/05/2020 Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) Give Comments
(Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid 701-116-0 - 07/05/2020 Reproductive toxicity (pre-natal developmental toxicity) Give Comments
2-isocyanatoethyl methacrylate 250-284-7 30674-80-7 07/05/2020 Reproductive toxicity (pre-natal developmental toxicity) Give Comments
Dioctyltin dilaurate 222-883-3 3648-18-8 07/05/2020 Reproductive toxicity (pre-natal developmental toxicity) Give Comments
(1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol 695-878-0 1283129-18-9
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide 686-241-8 81058-27-7
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
4-(1,1-dimethylethyl)cyclohexyl acrylate 282-104-8 84100-23-2
07/05/2020
07/05/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Etocrilene 226-029-0 5232-99-5
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Fluorobenzene 207-321-7 462-06-6
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea] 241-523-6 17526-94-2
07/05/2020
07/05/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine 695-748-3 65286-55-7
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated 846-447-2 1219458-07-7
09/04/2020
09/04/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate 261-665-2 59219-71-5 09/04/2020 Sub-chronic toxicity (90-day): oral Give Comments
Camphene 201-234-8 79-92-5 09/04/2020 Sub-chronic toxicity (90-day): oral Give Comments
4-tert-butylcyclohexyl acetate 250-954-9 32210-23-4 09/04/2020 Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with cis-4-tert-butylcyclohexyl acetate
Give Comments
29 resultaten.



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