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Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Alternatives to vertebrate testing

As of 11 September 2015 ECHA is inviting registrants that make testing proposals involving vertebrate animals for details on how they have considered alternative methods to address the missing information. This is a follow-up action of the European Ombudsman's conclusion in case 1606/2013 on 11 September 2015. A link to the registrant's considerations on alternatives to testing is published below with the related testing proposal. indicated The field is empty when the testing proposal was submitted before 11 September 2015 or when the registrant has not submitted a report on his considerations on alternatives to testing

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

23 resultaten.
 
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol 264-261-4 63469-23-8
12/03/2020
12/03/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
1-imino-1H-isoindol-3-amine 222-426-8 3468-11-9 12/03/2020 Genetic toxicity in vivo Give Comments
2,2'-isopropylidenebis(p-phenyleneoxy)diethanol 212-985-6 901-44-0
12/03/2020
12/03/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
2-(2-(2-butoxyethoxy)ethoxy)ethanol 205-592-6 143-22-6 12/03/2020 Reproductive toxicity (pre-natal developmental toxicity):
1st PNDT on the registered substance
2nd PNDT with the registered substance
// Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6)
Give Comments
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
12/03/2020
12/03/2020
12/03/2020
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile 300-496-1 93940-97-7
12/03/2020
12/03/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride 253-781-7 38103-06-9 12/03/2020 Sub-chronic toxicity (90-day): oral Give Comments
4,4'-methylenebis[N-sec-butylaniline] 226-122-6 5285-60-9 12/03/2020 Bioaccumulation aquatic / sediment Give Comments
4-chloroformylphthalic anhydride 214-874-8 1204-28-0 12/03/2020 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Give Comments
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate 220-482-8 2781-11-5 12/03/2020 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Give Comments
Diethyl ethylphosphonate 201-111-9 78-38-6
12/03/2020
12/03/2020
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Ethylenediamine, salt with phosphoric acid 238-914-9 14852-17-6 12/03/2020 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
m-phenylene di(acetate) 203-596-2 108-58-7 12/03/2020 Genetic toxicity in vivo Give Comments
N,N'-diphenyl-p-phenylenediamine 200-806-4 74-31-7
12/03/2020
12/03/2020
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant.
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine 264-438-6 63738-22-7 12/03/2020 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Give Comments
Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- 500-012-0 9004-77-7
12/03/2020
12/03/2020
12/03/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1).
Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - 12/03/2020 Reproductive toxicity (pre-natal developmental toxicity)
1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
Give Comments
Reaction products of monoethanolamine and boric acid (1:1) 701-025-6 -
12/03/2020
12/03/2020
12/03/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reaction products of monoethanolamine and boric acid (1:3) 701-024-0 -
12/03/2020
12/03/2020
12/03/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) 701-083-2 -
12/03/2020
12/03/2020
"Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) 947-369-2 -
12/03/2020
12/03/2020
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
tetrahydro-2-methylfuran 202-507-4 96-47-9
12/03/2020
12/03/2020
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Tetramethylammonium hydroxide 200-882-9 75-59-2 12/03/2020 Sub-chronic toxicity (90-day): oral
// Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8)
|| Note: Link to justification in the registration dossier not given as the information is confidential
Give Comments
23 resultaten.



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