4,8-Cyclododecadien-1-one

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11-03-2014 to 08-04-2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected: January 2013; signature: March 2013

Type of method:

differential scanning calorimetry

Melting / freezing pt.:

>= -33 - <= -30 °C

Atm. press.:

1 016.8 hPa

Decomposition:

no

Sublimation:

no

Remarks on result:

other: The substance has a freezing range of -33 to -30°C and a melting point of 11°C at 1016.8 hPa.

Table 1. Results of DSC analysis

Run Number	Sample Weight / mg	Onset of effect / °C	Range of Effect / °C	Air Pressure / hPa	Remarks
1	12.94	-29.74	-35 – -29 (exo)	1016.4	Cooling run (- 0.25 K/min)
		-11.15	-15 – 0 (endo)	1016.4	Heating run (+10 K/min)
		186.05	180 – 230 (exo)
		249.79	230 – 310 (endo)
2	13.43	-33.36	-35 – -30 (exo)	1016.8	Cooling run (- 0.25 K/min)
		-11.15	-15 – 0 (endo)	1016.8	Heating run (+10 K/min)
		184.39	180 – 230 (exo)
		254.79	230 – 310 (endo)

 

During cooling to -80°C, a distinct exothermic effect was detected in the temperature range -35 to -29°C which was associated with freezing of the test substance. As the onset temperatures in both tests deviate by more than 0.5 K from their mean value of -31.55°C, the test item has a freezing range of -33 to -30°C. During subsequent heating phases a distinct endothermic effect was observed in the temperature range of -15 – 0°C, which can be associated with the melting of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of -11.32°C, the test item has a melting point of -11°C.

Conclusions:

The freezing point range of the test item was -33 to -30 °C and the melting point was -11°C at 1016.8 hPa

Executive summary:

The freezing point range and melting point temperature of the test item was determined using EU Method A.1 and OECD TG 102: Differential Scanning Calorimetry (DSC) method. The test substance was tested in duplicate. The freezing point range of the test item was -33 to -30 °C and the melting point was -11°C at 1016.8 hPa pressure.

Description of key information

Freezing point range: >= -33 to <= -30 °C and Mp: -11°C at 1016.8 hPa (ca. 1 atmosphere), OECD TG 102 – DSC Method, 2014

Additional information

The freezing point range and melting point temperature of the test item was determined using EU Method A.1 and OECD TG 102: Differential Scanning Calorimetry (DSC) method. The test substance was tested in duplicate. The freezing point range of the test item was -33 to -30 °C and the melting point was -11°C at 1016.8 hPa  pressure. At temperatures greater than or equal to -11 °C (or 262 K) the test substance is a liquid at atmospheric pressure.