Registration Dossier
Registration Dossier
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EC number: 608-888-7 | CAS number: 33543-55-4
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Inhalation
Move exposed subject to fresh air. If not breathing, give artificial respiration (AR). If breathing is labored, administer oxygen. Get medical attention if symptoms occur.
Skin contact
Remove contaminated clothing/shoes. Wash exposed skin with soap and water. Get medical attention if symptoms occur.
Eye contact
If easy to do, remove contact lenses if worn. Immediately flush eyes with copious quantities of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention.
Ingestion
If swallowed, wash out mouth with water. Never give anything by mouth to an unconscious person. Get medical attention if symptoms occur.
Most important symptoms and effects, both acute and delayed
As a pharmaceutical intermediate, the toxicity and potency of this substance are not fully known. By toxicological expertise, the substance was assessed toxic due to potential hepatoxicity. Methemoglobinemia may develop, i.e. reduced ability for hemoglobin to carry oxygen which may appear as blue colorization of skin, lips and nails.
Indication of any immediate medical attention and special treatment needed
Treat symptomatically and supportively.
Move exposed subject to fresh air. If not breathing, give artificial respiration (AR). If breathing is labored, administer oxygen. Get medical attention if symptoms occur.
Skin contact
Remove contaminated clothing/shoes. Wash exposed skin with soap and water. Get medical attention if symptoms occur.
Eye contact
If easy to do, remove contact lenses if worn. Immediately flush eyes with copious quantities of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention.
Ingestion
If swallowed, wash out mouth with water. Never give anything by mouth to an unconscious person. Get medical attention if symptoms occur.
Most important symptoms and effects, both acute and delayed
As a pharmaceutical intermediate, the toxicity and potency of this substance are not fully known. By toxicological expertise, the substance was assessed toxic due to potential hepatoxicity. Methemoglobinemia may develop, i.e. reduced ability for hemoglobin to carry oxygen which may appear as blue colorization of skin, lips and nails.
Indication of any immediate medical attention and special treatment needed
Treat symptomatically and supportively.
Fire-fighting measures
Extinguishing media
•Suitable extinguishing media:
Use water spray, foam, dry powder or carbon dioxide as appropriate for surrounding fire and materials.
•Unsuitable extinguishing media:
No limitations given for this substance.
Special hazards arising from the substance or mixture
Combustible, but not flammable. In case of fire toxic fumes of nitrogen oxides (NOx) and carbon monoxide may be emitted.
No explosivity or flammability data identified. In general, high concentrations of finely divided airborne organic particles can potentially explode if ignited.
Advice for firefighters
In case of fire in the surroundings: use the appropriate extinguishing agent. Wear full protective clothing and an approved, positive pressure, self-contained breathing apparatus. Decontaminate all equipment after use.
•Suitable extinguishing media:
Use water spray, foam, dry powder or carbon dioxide as appropriate for surrounding fire and materials.
•Unsuitable extinguishing media:
No limitations given for this substance.
Special hazards arising from the substance or mixture
Combustible, but not flammable. In case of fire toxic fumes of nitrogen oxides (NOx) and carbon monoxide may be emitted.
No explosivity or flammability data identified. In general, high concentrations of finely divided airborne organic particles can potentially explode if ignited.
Advice for firefighters
In case of fire in the surroundings: use the appropriate extinguishing agent. Wear full protective clothing and an approved, positive pressure, self-contained breathing apparatus. Decontaminate all equipment after use.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use recommended personal protective equipment during removal of spillages.
Environmental precautions
Do not let the substance enter into drains. Avoid release to the environment.
Methods and material for containment and cleaning up
Moisten the powder spill with water prior to sweeping up. Keep in closed container and hold for waste disposal. Ventilate area and wash spill site with water after the pickup is completed.
Use recommended personal protective equipment during removal of spillages.
Environmental precautions
Do not let the substance enter into drains. Avoid release to the environment.
Methods and material for containment and cleaning up
Moisten the powder spill with water prior to sweeping up. Keep in closed container and hold for waste disposal. Ventilate area and wash spill site with water after the pickup is completed.
Handling and storage
Precautions for safe handling
Avoid breathing dust and contact with eyes and skin. Handle in well-ventilated areas. Use recommended personal protective equipment. Wash thoroughly after handling.
Conditions for safe storage, including any incompatibilities
Store at regular indoor conditions, generally 15-25°C. Keep container tightly closed.
Avoid breathing dust and contact with eyes and skin. Handle in well-ventilated areas. Use recommended personal protective equipment. Wash thoroughly after handling.
Conditions for safe storage, including any incompatibilities
Store at regular indoor conditions, generally 15-25°C. Keep container tightly closed.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 2811
Shipping information
- Proper shipping name and description:
- TOXIC SOLID, ORGANIC, N.O.S. (N-(4-nitrophenyloxy)-amine)
- Chemical name:
- (N-(4-nitrophenyloxy)-amine
- Language:
- English
- Labels:
- Special precautions: Tunnel code: D/E
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- N/A
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 2811
Shipping information
- Proper shipping name and description:
- TOXIC SOLID, ORGANIC, N.O.S. (N-(4-nitrophenyloxy)-amine)
- Chemical name:
- (N-(4-nitrophenyloxy)-amine)
- Labels:
- MFAG-No:154
- Marine pollutant
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 2811
Shipping information
- Proper shipping name and description:
- TOXIC SOLID, ORGANIC, N.O.S. (N-(4-nitrophenyloxy)-amine)
- Chemical name:
- (N-(4-nitrophenyloxy)-amine)
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Control parameters
To the best of our knowledge, established occupational exposure limit value is not available.
Exposure control
Appropriate engineering controls
The substance is considered to be a Category 2 of 4 (OEL 10- 500 microgram/m3, intermediate toxicity) compound based on its chemical structure, toxicological assessment and use as an intermediate. The objective containment, controls and work practices should be to contain worker breathing zone concentrations to below OEL for each task or operation. In general, Category 2 handling practices, some of which are described in general in this Section, are capable of achieving the OEL. However, verification of the acceptability of these Category 2 recommended containment, controls and work practices to meet the OEL through industrial hygiene monitoring of tasks or operations is recommended.
Selection and use of containment devices and personal protective equipment should be based on a risk assessment of exposure potential. Use local exhaust and/or enclosure at dust-generating points. Emphasis is to be placed on closed material transfer systems and process containment, with limited open handling of powders. High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an approved emission control or containment system.
Personal protective equipment
Eye face protection: Wear safety glasses with side shields. An emergency eyewash station should be available.
Skin protection Wear appropriate gloves, lab coat, or other protective overgarment if skin contact is likely. Base the choice of skin protection on the job activity, potential for skin contact and solvents and reagents in use.
Protective clothing Use impervious clothing to prevent skin contact. The type should be selected according to concentrations, quantitiesand duration of handling at the specific workplace. In dust generating operation use disposable coverall.
Respiratory protection Required when dusts are generated. Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. Use air-purifying respirator with combination filters for routine powder handling in process scale and positive-pressure air-supplied respirator if there is a potential of uncontrolled release. In the laboratory, use fume hood or laminar flow booth.
Environmental exposure controls : Avoid release to the environment and operate within closed systems wherever practical.
Other protective measures Wash hands in the event of contact with this substance, especially before eating, drinking and smoking. Protective equipment is not to be worn outside the work area (e.g. in common areas or out-of-doors). Decontaminate all protective equipment following use.
To the best of our knowledge, established occupational exposure limit value is not available.
Exposure control
Appropriate engineering controls
The substance is considered to be a Category 2 of 4 (OEL 10- 500 microgram/m3, intermediate toxicity) compound based on its chemical structure, toxicological assessment and use as an intermediate. The objective containment, controls and work practices should be to contain worker breathing zone concentrations to below OEL for each task or operation. In general, Category 2 handling practices, some of which are described in general in this Section, are capable of achieving the OEL. However, verification of the acceptability of these Category 2 recommended containment, controls and work practices to meet the OEL through industrial hygiene monitoring of tasks or operations is recommended.
Selection and use of containment devices and personal protective equipment should be based on a risk assessment of exposure potential. Use local exhaust and/or enclosure at dust-generating points. Emphasis is to be placed on closed material transfer systems and process containment, with limited open handling of powders. High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an approved emission control or containment system.
Personal protective equipment
Eye face protection: Wear safety glasses with side shields. An emergency eyewash station should be available.
Skin protection Wear appropriate gloves, lab coat, or other protective overgarment if skin contact is likely. Base the choice of skin protection on the job activity, potential for skin contact and solvents and reagents in use.
Protective clothing Use impervious clothing to prevent skin contact. The type should be selected according to concentrations, quantitiesand duration of handling at the specific workplace. In dust generating operation use disposable coverall.
Respiratory protection Required when dusts are generated. Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. Use air-purifying respirator with combination filters for routine powder handling in process scale and positive-pressure air-supplied respirator if there is a potential of uncontrolled release. In the laboratory, use fume hood or laminar flow booth.
Environmental exposure controls : Avoid release to the environment and operate within closed systems wherever practical.
Other protective measures Wash hands in the event of contact with this substance, especially before eating, drinking and smoking. Protective equipment is not to be worn outside the work area (e.g. in common areas or out-of-doors). Decontaminate all protective equipment following use.
Stability and reactivity
Reactivity
No known reactivity hazards under normal conditions.
Chemical stability
The substance is chemically stable at standard room temperature conditions, generally 15 to 25°C.
Possibility of hazardous reactions and conditions to avoid
None known.
Incompatible materials
Oxidants. Strong acids and bases.
Hazardous decomposition products
Carbon monoxide (CO) and nitrogen oxides (NOx).
No known reactivity hazards under normal conditions.
Chemical stability
The substance is chemically stable at standard room temperature conditions, generally 15 to 25°C.
Possibility of hazardous reactions and conditions to avoid
None known.
Incompatible materials
Oxidants. Strong acids and bases.
Hazardous decomposition products
Carbon monoxide (CO) and nitrogen oxides (NOx).
Disposal considerations
Waste treatment methods
Dispose of wastes in accordance to prescribed national, federal, state and local guidelines, e.g. appropriately permitted chemical waste incinerator.
Dispose of wastes in accordance to prescribed national, federal, state and local guidelines, e.g. appropriately permitted chemical waste incinerator.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
